Pityriasis Lichenoides: Anatomo-clinical Aspects and Follow-up Monocentric Retrospective Study
试验速览
- 阶段
- 不适用
- 入组人数
- 52
- 主要终点
- To study clinical Aspects of Pityriasis Lichenoides on a large series of adult patients
研究概览
简要总结
Introduction: Pityriasis lichenoides (PL) is an inflammatory dermatitis of undetermined origin consisting of specific papular lesions reflecting an "indolent" lymphoproliferative state.
The current classification is confusing because it mixes semiological and chronological notions.
The objectives of this study are to better describe the clinical, epidemiological, histological, phenotypic and evolutionary aspects of PL in an adult population.
Methods: Investigators will perform a retrospective cohort study including patients with clinical and histological diagnosis of PL from the coding of the Department of Pathology of Henri-Mondor Hospital and from medical records and photographs of lesions if available, between January 2012 and August 2018. A follow-up telephone interviews will also be proposed to each patient to collect evolution data. Photographs will be systematically reviewed as well as cutaneous samples and a genomic analysis will be performed.
Conclusion: Investigators would like to better understand clinical, histological features and evolutionary aspects of PL in an adult population.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Patients with Pityriasis Lichenoides selected from histological coding OT0431, seen at Henri Mondor and with a diagnosis verified from medical records.
排除标准
- •Histological coding error
- •Histological records of patients in care outside Henri Mondor (cases referred for histological expertise only but not seen clinically)
- •Clinical lesions incompatible with Pityriasis Lichenoides according to classically published semiological data
- •Missing or insufficient medical records for data exploitation
结局指标
主要结局
To study clinical Aspects of Pityriasis Lichenoides on a large series of adult patients
时间窗: It will be measured within 6 months of enrollment
Epidemiological and and clinical aspect description of the lesions from medical charts and photographs: age, sex, suspected trigger of the disease, past medical history, frequency of necrotic lesions, topography of lesions, fever, altered general conditions, treatment modalities of the flare.
次要结局
- To study histological features of Pityriasis Lichenoides(It will be measured within 6 months of enrollment)
- To study the number of outbreaks during patients' monitoring(It will be measured within 6 months of enrollment)
- To study molecular features of Pityriasis Lichenoides(It will be measured within 6 months of enrollment)
- To study the treatment during patients' monitoring(It will be measured within 6 months of enrollment)
- To study the duration of outbreak during patients' monitoring(It will be measured within 6 months of enrollment)
- To study the relapse during patients' monitoring(It will be measured within 6 months of enrollment)