Pityriasis Lichenoides : Anatomo-clinical Aspects and Follow-up
- Conditions
- Pityriasis Lichenoides
- Registration Number
- NCT03920696
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Brief Summary
Introduction: Pityriasis lichenoides (PL) is an inflammatory dermatitis of undetermined origin consisting of specific papular lesions reflecting an "indolent" lymphoproliferative state.
The current classification is confusing because it mixes semiological and chronological notions.
The objectives of this study are to better describe the clinical, epidemiological, histological, phenotypic and evolutionary aspects of PL in an adult population.
Methods: Investigators will perform a retrospective cohort study including patients with clinical and histological diagnosis of PL from the coding of the Department of Pathology of Henri-Mondor Hospital and from medical records and photographs of lesions if available, between January 2012 and August 2018. A follow-up telephone interviews will also be proposed to each patient to collect evolution data. Photographs will be systematically reviewed as well as cutaneous samples and a genomic analysis will be performed.
Conclusion: Investigators would like to better understand clinical, histological features and evolutionary aspects of PL in an adult population.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 52
- Age ≥ 18 years
- Patients with Pityriasis Lichenoides selected from histological coding OT0431, seen at Henri Mondor and with a diagnosis verified from medical records.
- Histological coding error
- Histological records of patients in care outside Henri Mondor (cases referred for histological expertise only but not seen clinically)
- Clinical lesions incompatible with Pityriasis Lichenoides according to classically published semiological data
- Missing or insufficient medical records for data exploitation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study clinical Aspects of Pityriasis Lichenoides on a large series of adult patients It will be measured within 6 months of enrollment Epidemiological and and clinical aspect description of the lesions from medical charts and photographs: age, sex, suspected trigger of the disease, past medical history, frequency of necrotic lesions, topography of lesions, fever, altered general conditions, treatment modalities of the flare.
- Secondary Outcome Measures
Name Time Method To study histological features of Pityriasis Lichenoides It will be measured within 6 months of enrollment The histological description will make use of a centralized re-reading of the slides according to a standardized grid (appearance of the epidermis, type and topography of the dermal infiltrate, results of the immunolabelings etc ...). The investigators aim to investigate the frequency of patients with patterns of pityriasis lichenoides mimicking lymphomatoid papulosis or mycosis fungoides and to correlate the histological aspect with clinical lesions.
To study the number of outbreaks during patients' monitoring It will be measured within 6 months of enrollment the number of outbreaks
To study molecular features of Pityriasis Lichenoides It will be measured within 6 months of enrollment number of clone T in the skin and in the blood.
To study the treatment during patients' monitoring It will be measured within 6 months of enrollment number of patients with need of a prolonged treatment
To study the duration of outbreak during patients' monitoring It will be measured within 6 months of enrollment the time to healing
To study the relapse during patients' monitoring It will be measured within 6 months of enrollment the number of relapses