Effectiveness of Fluid Deresuscitation With Central Venous Pressure Target 0-4 mmHg on Capillary Perfusion Density, Acute Kidney Injury Stage, Cardiac Index, and the Intensive Care Unit Length of Stay in Septic Shock Patients After Resuscitation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- Capillary Perfusion Density
研究概览
简要总结
A scientific research to prove the safety and effectiveness of TVS 0 - 4 mmHg as a target of resuscitation using furosemide, to improve Perfused Vessel Density (PVD) > 25 mm / mm2, AKI stage (based on KDIGO criteria), CI > 2.5 cc / min / m2 , prevent the incidence of intubation, reduce the duration of ventilator use <120 hours and reduce the length of ICU stay in patients with septic shock after resuscitation
详细描述
The study aims to evaluate the effectiveness of deresuscitation with target CVP 0 - 4 mmHg on septic shock patients in the ICU on capillary perfusion density, AKI stage (based on KDIGO criteria), the incidence of intubation, duration of use of mechanical ventilation, and length of stay in the ICU which can reduce the number of morbidity and mortality.
The study evaluates the difference in capillary perfusion density, AKI stage (based on KDIGO criteria), and the Cardiac index value between groups septic shock patients with CVP 0-4 mmHg on the 7th day after deresuscitation compared with the control group (CVP 8-10 mmHg on the first 7th day after being given deresuscitation).
The study evaluates the difference in the number of intubation incidents, duration of use ventilators, and care in the ICU between groups of patients with septic shock CVP 0 - 4 on day 28 after being given a degree of comparison with a control group (CVP 8-10 mmHg on day 28th after being deresuscitation).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Septic shock patients who meet the diagnosis criteria for quick SOFA and KDIGO 1 stage AKI (creatinine value 1.5 times OR creatinine value> 0.3 initial OR urine production <0.5 ml/kg/hour for 6-12 hours
- •Patients, both men and women, in the age range of 18 - 60 years
- •Patients who experience post clean operative sepsis
- •Patients who agree to attend the study by signing informed consent
排除标准
- •Patients with primary heart problems, right or heart failure suffer from congenital heart disease
- •Have severe chronic obstructive pulmonary disease, patients with severe pleural effusion
- •Patients who, based on ultrasound examination, found stones or tumors in the kidney during the study period
- •CKD patients are based on history taking and physical examination
- •DNR (do not resuscitate) patients
结局指标
主要结局
Capillary Perfusion Density
时间窗: 7 days
Capillary Perfusion Density measurement using MicroScan every 24 hours during deresuscitation
次要结局
- Cardiac Index(7 days)
- Neutrophil Gelatinase-Associated lipocalin (NGAL)(1st and 7th day)
- Renal Resistive Index (RRI)(1st and 7th day)
- Acute Kidney Injury Stage(7 days)
- Length of ICU stay(28 days)
研究者
Dita Aditianingsih
MD, PhD, Anesthesiologist Consultant
Indonesia University