The effects of Theta-burst Transcranial Magnetic Stimulation over Contralesional Premotor Area and Contralesional Primary Motor Cortex on Post-stroke Spasticity in Patients with Severe Hemiplegia
- Conditions
- stroke
- Registration Number
- ChiCTR2200060885
- Lead Sponsor
- Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1.Age 18–80 years old, regardless of gender;<br>2.First unilateral stroke (cerebral infarction, primary intracerebral hemorrhage, subarachnoid hemorrhage) confirmed by MRI or CT within 6 months before enrolment;<br>3.Perceptible muscle spasticity with MAS score >1; <br>4.Severe motor impairment with the Fugl-Meyer Assessment of Upper Extremity (FMA-UE) score 0-35;<br>5.Failure to induce MEP in the upper extremity of the hemiplegic side; <br>6.Mini-Mental State Examination (MMSE) score >= 22 and compliance with the interventions;<br>7.Sign the informed consent.
1.More than one stroke (patients with previous transient ischemic attack could participate), bilateral cerebral hemisphere lesion;<br>2.History of seizures or seizures after stroke, severe skull fracture;<br>3.Conditions unsuitable for TBS, e.g. intracranial implants, cardiac pacemakers or pregnancy, implanted drug pumps, etc.;<br>4.Medications that may lower the seizure threshold have been used continuously for nearly 6 months. <br>5.Serious impairments of heart, lung, liver, kidney, and other organs, cannot tolerate training; <br>6.Participation in other spasticity rehabilitation studies.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fugl-Meyer assessment scale of the upper extremity;MAS;
- Secondary Outcome Measures
Name Time Method H reflex and M response;Startle reflex;MEP;DTI;