Accelerated Theta Burst Stimulation (TBS) in the Treatment of Depressio

Not Applicable

• Conditions: depression; Mental Health - Depression

• Registration Number: ACTRN12616000443493
• Lead Sponsor: Professor Paul Fitzgerald

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-04-06
• Study Completion: 2019-01-15
• Last Update Posted: 27 June 2022

Recruitment & Eligibility

• Status: Stopped early
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

DSM-IV diagnosis of Major Depressive Disorder (MINI)
- HAMD score of > 20 (moderate - severe depression)
- no increase or initiation of new antidepressant therapy in 4 weeks prior to screening
- have treatment resistant depression (stage II of Thase and Rush classification)
- have had no increase or initiation of new antidepressant therapy in the four weeks prior to screening

Exclusion Criteria

- unstable medical condition, neurological disorder, history of seizure disorder, pregnant or lactating
- metal in the head, except in mouth, which may interfer with the magnetic field
- current DSM-IV diagnosis of substance abuse or dependence disorder, a diagnosis of a personality disorder or another Axis 1 disorder

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Montgomery Asperg Depression Rating Scale (MADRS)[Baseline and weekly for 4 weeks. The week 4 review is to be conducted immediately after treatment completion.]