Prospective Cohort Study of the Effect of Bariatric/Metabolic Surgery on Morbid Obesity Patients With Metabolic Syndrome
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change in Glomerular filtration rate
研究概览
简要总结
The purpose of this study is to determine the change in kidney function and blood pressure after gastric bypass versus conventional medical therapy in morbid obesity. The study mainly focus on glomerular filtration rate(GFR) with known relation to the renal function and 24 hours ambulatory blood pressure monitoring after intervention of gastric bypass or medical treatment.
详细描述
Metabolic syndrome is strongly associated with obesity and the patients with this syndrome are at increased risk for cardiovascular disease. Obesity constitutes a strong risk factor for the development of chronic kidney disease. Among diabetics, obesity is known to amplify the risk for kidney disease. Bariatric surgery has yielded dramatic results including longitudinal loss of excess body weight and either complete reversal or significant improvement of several features of metabolic syndrome. In addition, many observational studies have demonstrated significant reduction in proteinuria after bariatric surgery.
However, the changes in the component of cardiovascular problem among metabolic syndrome and changes in renal filtration function or progression to end stage kidney disease in morbidly obese patients after weight loss surgery have not been extensively studied. Therefore, our study mainly focus on glomerular filtration rate(GFR) with known relation to the renal function and 24 hours ambulatory blood pressure monitoring after intervention of gastric bypass or medical treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Morbid obesity (BMI>30) patients with one of comorbidity (type 2 diabetes, dyslipidemia, or hypertension)
- •Morbid obese patients (BMI>35)
排除标准
- •Prior bariatric surgery
- •Malignancy (any type)
- •End stage renal disease
研究组 & 干预措施
Obese patients
15 Obese patients (BMI>30) having one of comorbidity (type 2 diabetes, dyslipidemia, or hypertension) and morbid obese patients (BMI>35) accepted for bariatric surgery.
干预措施: Bariatric surgery (Procedure)
Control patients
15 matched controls receiving Intensive medical therapy
结局指标
主要结局
Change in Glomerular filtration rate
时间窗: before, 6, 12month after surgery
次要结局
- Change in excessive body weight(before, 6, 12month after surgery)
- Systolic function (EF)(Before, 6 and 12month after surgery)
- Diastolic function (E,A,DT,IVRT,E/e')(Before, 6 and 12month after surgery)
- Change of daytime blood pressure (systolic blood pressure, diastolic blood pressure, mean blood pressure)(Before, 6, and 12month after surgery)
- Change of night time blood pressure (systolic blood pressure, diastolic blood pressure, mean blood pressure)(Before, 6, and 12month after surgery)
- Change of 24 hours blood pressure (systolic blood pressure, diastolic blood pressure, mean blood pressure)(Before, 6, and 12month after surgery)
研究者
Tae Kyung Ha
Associate Professor
Hanyang University