Prospective Cohort Study of the Effect of Bariatric/Metabolic Surgery on Morbid Obesity Patients With Metabolic Syndrome
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Metabolic Syndrome
- Sponsor
- Hanyang University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Change in Glomerular filtration rate
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to determine the change in kidney function and blood pressure after gastric bypass versus conventional medical therapy in morbid obesity. The study mainly focus on glomerular filtration rate(GFR) with known relation to the renal function and 24 hours ambulatory blood pressure monitoring after intervention of gastric bypass or medical treatment.
Detailed Description
Metabolic syndrome is strongly associated with obesity and the patients with this syndrome are at increased risk for cardiovascular disease. Obesity constitutes a strong risk factor for the development of chronic kidney disease. Among diabetics, obesity is known to amplify the risk for kidney disease. Bariatric surgery has yielded dramatic results including longitudinal loss of excess body weight and either complete reversal or significant improvement of several features of metabolic syndrome. In addition, many observational studies have demonstrated significant reduction in proteinuria after bariatric surgery. However, the changes in the component of cardiovascular problem among metabolic syndrome and changes in renal filtration function or progression to end stage kidney disease in morbidly obese patients after weight loss surgery have not been extensively studied. Therefore, our study mainly focus on glomerular filtration rate(GFR) with known relation to the renal function and 24 hours ambulatory blood pressure monitoring after intervention of gastric bypass or medical treatment.
Investigators
Tae Kyung Ha
Associate Professor
Hanyang University
Eligibility Criteria
Inclusion Criteria
- •Morbid obesity (BMI\>30) patients with one of comorbidity (type 2 diabetes, dyslipidemia, or hypertension)
- •Morbid obese patients (BMI\>35)
Exclusion Criteria
- •Prior bariatric surgery
- •Malignancy (any type)
- •End stage renal disease
Outcomes
Primary Outcomes
Change in Glomerular filtration rate
Time Frame: before, 6, 12month after surgery
Secondary Outcomes
- Change in excessive body weight(before, 6, 12month after surgery)
- Systolic function (EF)(Before, 6 and 12month after surgery)
- Diastolic function (E,A,DT,IVRT,E/e')(Before, 6 and 12month after surgery)
- Change of daytime blood pressure (systolic blood pressure, diastolic blood pressure, mean blood pressure)(Before, 6, and 12month after surgery)
- Change of night time blood pressure (systolic blood pressure, diastolic blood pressure, mean blood pressure)(Before, 6, and 12month after surgery)
- Change of 24 hours blood pressure (systolic blood pressure, diastolic blood pressure, mean blood pressure)(Before, 6, and 12month after surgery)