Prophylactic cranial irradiation with hippocampal sparing technique in small cell lung cancer patients

Phase 2

Recruiting

• Conditions: Patients who is diagnosed small cell lung cancer and fulfilled criterion for prophylactic cranial irradiation will be enrolled to this study; hippocampal sparing, prophylactic cranial irradiation, small cell lung cancer

• Registration Number: TCTR20200725001
• Lead Sponsor: Faculty of Medicine, Chiang Mai University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-07-25
• Study Completion: 2020-10-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

1.age 18 to 80 years old
2.ECOG 0-2
3.histopathological diagnosed small cell lung cancer
4.no evidence of brain metastasis on cranial-MRI
5.no progression of primary tumor and/or extra-cranial metastasis after complete standard treatment (chemotherapy and/or thoracic radiotherapy)

Exclusion Criteria

1.history of previous cranial irradiation
2.evidence of leptomeningeal dissemination

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of hippocampal metastasis after cranial irradiation serial MRI and physical examination

Secondary Outcome Measures

Name	Time	Method
cognitive function, 2-yr overall survival, rate of brain metastasis after cranial irradiation TMSE, serial MRI and physical examination