A Randomized Double-blind Placebo-controlled Trial to Working Memory Training in Substance Abusers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 180
- 试验地点
- 2
- 主要终点
- Craving: Desires for Alcohol Questionnaire and Desires for Drug Questionnaire score change and Obsessive Compulsive Drug Use Scale and Obsessive Compulsive Drinking Scale score change between pre and post training and follow up (two months after post)
研究概览
简要总结
Background: Substance abusers show impaired working memory (WM) functioning. Promising findings show training WM results in an improved working memory capacity (WMC) and a decrease of clinical symptoms in a range of disorders, including alcohol addiction.
Aim: To test the effect of a WM training in addition to treatment as usual (TAU) on substance use, craving, WMC, impulsivity, attention bias and psychopathology.
Design: A randomized double-blind placebo-controlled trial with a parallel group design. The WM training adapted to participants' WMC whereas the placebo training consisted of non-adaptive easy versions of these tasks.
Setting: Two departments of an addiction treatment clinic in Rotterdam, the Netherlands.
Participants: 120 inpatients diagnosed with an alcohol, cannabis or cocaine dependency who were in treatment as usual .
Measurements: Primary outcome measures: Substance use and craving. Secondary outcome measures: WMC, impulsivity, attention bias and psychopathology. Participants were assessed before and after 24 sessions of WM training as well as two months after the training.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 16 Years 至 67 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Substance dependency: cocaine, cannabis or alcohol
排除标准
- •Age below 16 or above 67
- •Current psychosis
- •Neurological complaints
结局指标
主要结局
Craving: Desires for Alcohol Questionnaire and Desires for Drug Questionnaire score change and Obsessive Compulsive Drug Use Scale and Obsessive Compulsive Drinking Scale score change between pre and post training and follow up (two months after post)
时间窗: Pre (baseline), post (after 4 weeks of training-starting 1 day after pre-test) and follow-up (2 months after post-test)
The 14-item Desires for Drug Questionnaire (DDQ) and the 13-item Desires for Alcohol Questionnaire (DAQ) measure instant craving to respectively drug and alcohol. The DDQ is based on the DAQ. The Obsessive Compulsive Drug Use Scale (OCDUS) and Obsessive Compulsive Drinking Scale (OCDS) measure the subjective interference and distress caused by respectively drug and alcohol related thoughts and compulsive-behavior patterns.
次要结局
- Change in Digit Span score on pre and post training and follow up after two months(Pre (baseline), post (after 4 weeks of training-starting 1 day after pre-test) and follow-up (2 months after post-test))
- Change in Reading Span partial-scredit uni score on pre and post training and follow up after two months(Pre (baseline), post (after 4 weeks of training-starting 1 day after pre-test) and follow-up (2 months after post-test))
研究者
Ingmar Franken
Professor
Erasmus Medical Center