Impact of Platelet Activation in Intracranial Aneurysm Rupture Risk - PLAQRAN

Active, not recruiting

• Conditions: Ruptured Aneurysm; Intracranial Aneurysms

• Registration Number: NCT03408379
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

Sub arachnoid hemorrhage consecutive to intracranial aneurysm rupture is a devastating disease. Predictors of intracranial aneurysm rupture are limited and focus mainly on size and location. Platelet activation may have a deleterious role on aneurysm rupture. The assumption is that patients with ruptured intracranial aneurysm will present a higher rate of platelet activation compared to patients with non ruptured aneurysms.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-12-20
• Study First Submitted: 2018-01-17
• Study First Submitted QC: 2018-01-23
• Study First Posted: 2018-01-24
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-06
• Last Update Posted: 2023-07-07
• Primary Completion: 2027-12-20
• Study Completion: 2028-08

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 230

Inclusion Criteria

• Patient aged 18 and over
• Patient presenting a single or multiple aneurysm
• Patient presenting an intracranial aneurysm for which an intervention is planned (endovascular treatment or surgery) : elective intervention for an unruptured aneurysm or emergency surgery for a broken aneurysm

Exclusion Criteria

• Pregnant or breast feeding woman

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of patients with platelet activation	in the 7 days before embolisation	comparison of this proportion between patients with ruptured versus non ruptured intracranial aneurysm

Trial Locations

Locations (1)

Fondation Ophtalmologique A. de Rothschild; 🇫🇷 Paris, France