Effects of therapeutic intervention on working memory in Parkinson's disease patients.

Not Applicable

• Conditions: G20; Parkinson disease

• Registration Number: DRKS00032579
• Lead Sponsor: niversity Hospital Giessen and Marburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-06-25
• Study Start: 2023-09-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Confirmed diagnosis of idiopathic Parkinson's syndrome
- Implanted THS electrode in the Department of Neurosurgery of the UKGM Marburg (target area: STN)
- German as mother tongue
- Right-handedness
- Duration of implantation longer than three months
- Willingness to participate in EEG examinations
- Ability to understand the subject information and to give written consent
- Written consent for voluntary participation in the study

Exclusion Criteria

- Central neurological or severe psychiatric disease
- Presence of atypical or secondary parkinsonian syndrome
- Prior CNS surgery other than THS implantation.
- Mild Cognitive Impairment (MCI, PANDA, see Appendix 3))
- Regular use of medications affecting the CNS that have not been discontinued the evening before the examination until after the examination.
- Severe, non-compensable hearing or visual impairment
- Chronic alcohol or drug abuse in the past two years
- Pregnancy or lactation
- Legal incapacity
- Court-ordered or government-ordered institutionalization
- Only in the case of obtaining new MRI scans: Common MRI exclusion criteria
(cardiac pacemaker, implanted ferromagnetic objects, non-MRI compatible THS electrode)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Working memory performance measured by a modified Sternberg task