Investigation of the preventive effects of antimicrobial penetrated collargen plug(TERUPLUG) for post-extraction tooth socket for osteonecrosis of the jaw after tooth extraction in patients using high-dose antiresorptive agent

Phase 2

• Conditions: Patients receiving high-dose antiresorptive agent; high-dose antiresorptive agent, osteonecrosis

• Registration Number: JPRN-jRCTs071200006
• Lead Sponsor: Soutome Sakiko

Brief Summary

The local administration of atelocollagen/minocycline in the extraction socket may reduce the risk of MRONJ following tooth extraction.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-20
• Study Completion: 2022-10-25
• Last Update Posted: 27 May 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

Patients receiving ZOMETA or RANMARK therapy who are planned to undergo tooth extraction

Exclusion Criteria

Patients with problem in judgement

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of MRONJ 2 months later after tooth extraction

Secondary Outcome Measures

Name	Time	Method
Association of investigation factors and onset of MRONJ