Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)

Terminated

• Conditions: Kidney Failure, Acute; Critical Illness

• Registration Number: NCT00316576
• Lead Sponsor: University Hospital, Caen

Brief Summary

Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.

Detailed Description

Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.

Study Timeline

• Study First Submitted: 2006-04-19
• Study First Submitted QC: 2006-04-19
• Study First Posted: 2006-04-21
• Study Start: 2006-05
• Study Completion: 2006-11
• Status Verified: 2008-01
• Last Update Submitted: 2008-01-16
• Last Update Posted: 2008-01-17

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• Age > 18 yrs
• ICU stay > 48 hours

Exclusion Criteria

• Age < 18 yrs
• Creatinine > 180 µmol/L
• Absence of consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of ARF	During ICU stay

Secondary Outcome Measures

Name	Time	Method
Mortality	ICU and Hospital mortality

Trial Locations

Locations (1)

Medical Intensive care Unit; Caen University Hospital; 🇫🇷 Caen, France