The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome

• Conditions: Sick Sinus Syndrome
• Interventions: Other: observation

• Registration Number: NCT01310920
• Lead Sponsor: China Medical University Hospital

Brief Summary

Evidence has been documented for the close relationship between the arrhythmia pathogenesis and the gene expression in renin-angiotensin system. However, it remains unclear for involvement of RAS in the pathogenesis of non-familial sick sinus syndrome. The researchers thus investigated the possible relationship between non-familial sick sinus syndrome and the polymorphism and haplotype of the AGT promoter.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-02
• Status Verified: 2011-03
• Study First Submitted: 2011-03-06
• Study First Submitted QC: 2011-03-08
• Last Update Submitted: 2011-03-08
• Study First Posted: 2011-03-09
• Last Update Posted: 2011-03-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• sick sinus syndrome

Exclusion Criteria

• 1.Severe systemic disease.
• 2.Acute coronary syndrome.
• 3.bradycardia with reversible cause.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
sick sinus syndrome	observation	-

Trial Locations

Locations (1)

China Medical University Hospital; 🇨🇳 Taiwan, Taiwan