A-prf,Nanochitosan Combined With A-prf Compared to Chitosan for Symptomatic Irreversible Pulpitis of Mature Teeth
- Conditions
- Pulpitis - Irreversible
- Interventions
- Procedure: PULPOTOMY OF MATURE PERMENANT TEETH
- Registration Number
- NCT06438523
- Lead Sponsor
- Future University in Egypt
- Brief Summary
Clinical and radiographic assessment of A-prf,A-prf combined with nanochitosan compared to chitosan for symptomatic irreversible pulpits in lower permanent first molar
- Detailed Description
3 groups are allocated using : Aprf Aprf combined with nanochitosan Chitosan
Each group will be subjected to tests:
Tooth sensibility via EPT (electrical pulp tester)and thermal test Radiolucency in digital radiograph Pain in NRS(6-12-24-72h)for 1 week
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 30
-
Patients suffering from Symptomatic irreversible pulpitis in mature mandibular molars only will be involved.
- Patients of either gender aged from 15-30.
- Tooth should give positive response to cold test.
- Haemostasias should be achieved after total pulpotomy.
- The tooth is restorable and free from advanced periodontal disease, cracks and splits.
- Patients should be free from any systemic disease that may affect normal healing and predictable outcome.
- Patients who will agree to the consent and will commit to follow-up period.
- Patients with mature root.
- Patients with no internal or external resorption and no periapical lesions.
- Soft tissues around the tooth are normal with no swelling or sinus tract.
-
Patients with immature roots.
- Haemostasias after 10 minutes can not be controlled after total pulpotomy
- Patients with any systemic disease that may affect normal healing.
- Patients with periapical lesions or infections.
- Pregnant females.
- Patients who could/would not participate in a 6 months follow-up.
- Patients with fistula or swelling
- Patients with necrotic pulp.
- Patients with old age.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description chitosan PULPOTOMY OF MATURE PERMENANT TEETH he access cavity will be prepared up to the level of pulp chamber floor using sterile round diamond bur size 1 in high-speed hand piece with coolant.Once the pulp has been reached, a sharp sterile excavator should be used to remove the pulp tissue to the level of the radicular/root canal orifices then chitosan will be applied Advanced Platelet rich fibrin,A-prf,A-PRF scaffold PULPOTOMY OF MATURE PERMENANT TEETH A-PRF will be prepared according to Choukroun's technique by drawing whole blood from the median cubital vein into a 10 ml plain plastic test tubes (non-citrated) without the addition of an anticoagulant reagent . To prevent the blood from coagulating, it will be centrifuged immediately using a table top centrifuge at 1500 rpm for 14 minute. A-prf mixed with nano chitosan PULPOTOMY OF MATURE PERMENANT TEETH A-PRF will be prepared according to Choukroun's technique by drawing whole blood from the median cubital vein into a 10 ml plain plastic test tubes (non-citrated) without the addition of an anticoagulant reagent . To prevent the blood from coagulating, it will be centrifuged immediately using a table top centrifuge at 1500 rpm for 14 minute then mixed with nanochitosan
- Primary Outcome Measures
Name Time Method pain assessment 6,12,24,72hours and 7 days postoperative Pain assessment using numerical rate scale
- Secondary Outcome Measures
Name Time Method Clinical and radiographic success 1,3,6,9and 12 months It includes clinical and radiographic success if either of them failed the case will considered failed.
Clinical failure :signs and symptoms of inflammation or infection Radiograph success and failure based on periapical index
Trial Locations
- Locations (1)
Future university
🇪🇬Cairo, Fifth Settlement, Egypt