Effects of Treatment With High Flow Nasal Cannulas on Respiratory Pattern and Work of Breathing Among Healthy Subjects
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Laval University
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Work of breathing
Study Overview
Brief Summary
This study evaluates the work of breathing among healthy subjects under various conditions of treatment with high flow nasal cannulas. Ten subjects will be included. The design of this study is a cross over of five treatment periods with different flow settings.
Detailed Description
High flow oxygen therapy (HFOT) is a promising technique increasingly used in the management of acute respiratory failure. In hospitalised hypoxemic patients, recent clinical evidence showed that HFOT can reduce endotracheal intubation and reduce mortality. Physiologically, the HFOT causes a decrease in respiratory rate and minute-ventilation and may be associated with a decrease in carbone dioxyde arterial pressure. It is possible that these effects are associated with decreased work of breathing, which could explain some of the benefits in terms of comfort and efficiency.
The objective of this research is to evaluate the impact of a wash-out of anatomical dead space by high flow nasal cannulas on respiratory parameters and on the work of breathing among healthy subjects. The investigators will evaluate the baseline status in room air, and then compare it with four different levels of flow. The primary endpoint will be the work of breathing.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy subjects
- •Written and informed consent
Exclusion Criteria
- •Pregnant or breastfeeding women;
- •Subject enrolled in another study excluding co-enrolment;
- •Cardio-vascular or respiratory disease;
- •History of ear nose and throat disease (i.e. surgery, epistaxis, trauma), eso-gastric disease (i.e. esophageal varices, digestive haemorrhage), rheumatologic or neurologic disease possibly interfering with the design of the study;
- •Subject feeling nauseous or under recent fed condition (<1h).
Arms & Interventions
No flow
Subjects will be spontaneously breathing in room air with no flow.
Conventional flow via nasal prongs
Subjects will be breathing with nasal prongs delivering 5 L/min of air (inspired fraction of oxygen: 0.21)
Intervention: Conventional flow via nasal prongs (Device)
High flow nasal cannulas 20 L/min
Subjects will be breathing with high flow nasal cannulas delivering 20 L/min with an inspired fraction of oxygen of 0.21.
Intervention: High flow nasal cannulas (Device)
High flow nasal cannulas 40 L/min
Subjects will be breathing with high flow nasal cannulas delivering 40 L/min with an inspired fraction of oxygen of 0.21.
Intervention: High flow nasal cannulas (Device)
High flow nasal cannulas 60 L/min
Subjects will be breathing with high flow nasal cannulas delivering 60 L/min with an inspired fraction of oxygen of 0.21.
Intervention: High flow nasal cannulas (Device)
Outcomes
Primary Outcomes
Work of breathing
Time Frame: 10 minutes
Work of breathing at the end of each period is calculated from the measurement of esophageal pressure and tidal volume (composite outcome).
Secondary Outcomes
- Heart rate(10 minutes)
- Blood gases(10 minutes)
- Comfort of breathing(10 minutes)
- Tidal Volume(10 minutes)
- End-tidal carbon dioxide(10 minutes)
- Dyspnea(10 minutes)
- Respiratory Rate(10 minutes)
- Oxygen saturation(10 minutes)
- Esophageal pressure-time product(10 minutes)