Nosocomial Bacterial and Fungal Chest Infections in Cirrhotic Patients

• Conditions: Nosocomial Infection
• Interventions: Diagnostic Test: Diagnosis of bacterial infections

• Registration Number: NCT03413293
• Lead Sponsor: Assiut University

Brief Summary

Hospital acquired chest Infections are common complications in hospitalized cirrhotic patients. Infectious complications are the most common cause of mortality in cirrhotic patients with bronchopneumonia early antibiotic treatment at the base of culture and sensitivity is an optimal therapeutic approach in cirrhotics with nosocomial pneumonia Intensive care unit acquired pneumonia is the leading infection in critically ill patients and a major cause of morbidity and mortality despite recent major advances in antimicrobial therapy, supportive care, and the use of a broad range of preventive measures

Detailed Description

Aim of the work

1. To estimate the frequency and risk factors of nosocomial chest infections in cirrhotic patients .

2. To determine the causative pathogens of nosocomial chest infections in patients with cirrhosis including fungal infections in order to establish our local empirical antimicrobial protocol.

3. To define the impact of nosocomial chest infections on survival of our patients.

4. To develop an effective and continuous surveillance program and infection control measures to reduce the burden of these infections as well as morbidity , mortality , hospital stay ,hospital cost and to achieve quality of care .

5. To motivate pharmaceutical companies to create a new umbrella coverage of antimicrobials through the ongoing knowledge of the changes in microbial resistance pattern inside hospitals

Study Timeline

• Study First Submitted: 2018-01-08
• Study First Submitted QC: 2018-01-22
• Study First Posted: 2018-01-29
• Status Verified: 2018-02
• Last Update Submitted: 2018-05-16
• Last Update Posted: 2018-05-18
• Study Start: 2018-06
• Primary Completion: 2019-05
• Study Completion: 2019-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• All cirrhotic patients , decompensated , child pug score B or C ,may have Hepatocellular carcinoma , other comorbidities may present as (Diabetius mellitus , Hypertension , Heart disease and renal impairment ) , both sex and with clinical suspicion of chest infections acquired after 48 hours of admission

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Exclusion Criteria

• Patients have any chronic chest disease
• Patients have severe immunosuppression (neutropenia after chemotherapy or hematopoietic transplant, drug-induced immunosuppression in solid-organ transplant or cytotoxic therapy, and HIV-related disorders.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Nosocomial infected cirrhotic patients	Diagnosis of bacterial infections	-

Primary Outcome Measures

Name	Time	Method
Frequency of nosocomial infection in patients with liver cirrhosis	baseline	nosocomial infection is one of predictors of bad outcome in liver cirrhosis