Nosocomial Bacterial and Fungal Chest Infections in Cirrhotic Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 主要终点
- Frequency of nosocomial infection in patients with liver cirrhosis
研究概览
简要总结
Hospital acquired chest Infections are common complications in hospitalized cirrhotic patients. Infectious complications are the most common cause of mortality in cirrhotic patients with bronchopneumonia early antibiotic treatment at the base of culture and sensitivity is an optimal therapeutic approach in cirrhotics with nosocomial pneumonia Intensive care unit acquired pneumonia is the leading infection in critically ill patients and a major cause of morbidity and mortality despite recent major advances in antimicrobial therapy, supportive care, and the use of a broad range of preventive measures
详细描述
Aim of the work
- To estimate the frequency and risk factors of nosocomial chest infections in cirrhotic patients .
- To determine the causative pathogens of nosocomial chest infections in patients with cirrhosis including fungal infections in order to establish our local empirical antimicrobial protocol.
- To define the impact of nosocomial chest infections on survival of our patients.
- To develop an effective and continuous surveillance program and infection control measures to reduce the burden of these infections as well as morbidity , mortality , hospital stay ,hospital cost and to achieve quality of care .
- To motivate pharmaceutical companies to create a new umbrella coverage of antimicrobials through the ongoing knowledge of the changes in microbial resistance pattern inside hospitals
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All cirrhotic patients , decompensated , child pug score B or C ,may have Hepatocellular carcinoma , other comorbidities may present as (Diabetius mellitus , Hypertension , Heart disease and renal impairment ) , both sex and with clinical suspicion of chest infections acquired after 48 hours of admission
排除标准
- •Patients have any chronic chest disease
- •Patients have severe immunosuppression (neutropenia after chemotherapy or hematopoietic transplant, drug-induced immunosuppression in solid-organ transplant or cytotoxic therapy, and HIV-related disorders.
结局指标
主要结局
Frequency of nosocomial infection in patients with liver cirrhosis
时间窗: baseline
nosocomial infection is one of predictors of bad outcome in liver cirrhosis
次要结局
未报告次要终点
研究者
NZBakhiet
resident doctor
Assiut University