Effects of high intensity interval training on skeletal muscle metabolism and oxygenation in patients with chronic heart failure

Completed

• Conditions: chronic heart failure; left ventricular dysfunction; 10019280

• Registration Number: NL-OMON38340
• Lead Sponsor: Maxima Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Written informed consent
Stable systolic heart failure secondary to ischemic or dilated cardiomyopathy
New York Heart Association (NYHA) class II or III (without change in class or medication < 3 months prior to inclusion)
Left ventricular ejection fraction of * 40% (assessed within 3 months before inclusion by echocardiography, MRI or radionuclear measurement)

Exclusion Criteria

Myocardial infarction or unstable angina less than 3 months prior to inclusion
Clinical signs of decompensated heart failure
Ventricular tachycardia or ischemia during exercise
Participation in a training program (* 2/week) in the last year
Intracardiac shunts or congenital heart disease limiting exercise capacity
Orthopaedic, vascular, pulmonary, neuromuscular and other disease limiting exercise capacity
MRI will not be a part of the study protocol in eligible patients with pacemaker / implantable cardioverter defibrillator (ICD) or other contra indication for magnetic resonance imaging

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Changes in skeletal muscle metabolic recovery after submaximal exercise (leg<br /><br>extension in the supine position) are assessed by 31P MR spectroscopy<br /><br>measurements in M. vastus lateralis (rate of post-exercise phosphocreatine<br /><br>increase, expressed as * -PCr). Changes in skeletal muscle re-oxygenation are<br /><br>assessed simultaneously at the same location by Near Infrared Spectroscopy<br /><br>(rate of post-exercise decrease in deoxygenated hemoglobin, expressed as<br /><br>MRT-HHb). Changes in physiological aspects of skeletal muscle oxygenation and<br /><br>metabolism are assessed by oxidative enzyme activity (succinate dehydrogenase<br /><br>and cytochrome-C-oxidase activity), muscle fibre type distribution and<br /><br>capillary density.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Changes in maximal exercise capacity (peak Vo2) and submaximal exercise<br /><br>capacity (rate of recovery of oxygen uptake and re-oxygenation after submaximal<br /><br>exercise), left ventricular function (left ventricular ejection fraction and<br /><br>end systolic volume) and Quality of life (Minnesota living with heart failure<br /><br>questionnaire).</p><br>