Patient controlled analgesia (PCA) versus continuous infusion (CI) of morphine during vaso-occlusive crisis in sickle cell disease (SCD): a randomised controlled trial
Completed
- Conditions
- Sickle cell diseaseHaematological DisordersSickle-cell disorders
- Registration Number
- ISRCTN74336585
- Lead Sponsor
- Academic Medical Centre (AMC) (The Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
1. Sickle cell disease defined as HbSS, HbSC or HbSA (by electrophoresis)
2. Age greater than 17 years
3. The presence of typical pain recognised by patients as originating from vaso-occlusive crisis and which cannot be explained by other causes
4. Severe pain necessitating treatment with intravenous morphine
5. Written informed consent
Exclusion Criteria
1. Patients already receiving opioids for more than 24 hours at time of randomisation
2. Allergy or intolerance for morphine
3. Pregnancy
4. Chronic use of opioids
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method