24-Weeks of β-Alanine Ingestion on Muscle Taurine and Clinical Blood Parameters in Healthy Males
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Sao Paulo
- Enrollment
- 25
- Primary Endpoint
- Muscle taurine content in mmol/kg
Study Overview
Brief Summary
Although β-alanine (BA) has been shown to be an effective ergogenic aid, little information exists on the safety of chronic supplementation despite potential concerns. The aim of this study was to investigate the effects of chronic BA supplementation on muscle taurine content, blood clinical markers and sensory side-effects during 24 weeks of BA supplementation.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy males
Exclusion Criteria
- •Chronic disease
- •Prior or current use of steroids
- •Use of creatine in the last 6 months
- •Use of beta-alanine in the last 6 months
Arms & Interventions
Placebo
6.4 g/day of maltodextrin for 24 weeks
Intervention: Placebo (Dietary Supplement)
Beta-Alanine
6.4 g/day of beta-alanine for 24 weeks
Intervention: Beta-alanine (Dietary Supplement)
Outcomes
Primary Outcomes
Muscle taurine content in mmol/kg
Time Frame: Up to 24 weeks
Change in the content of taurine in muscle will be determined using High-Pressure Liquid Chromatography of muscle biopsies
Secondary Outcomes
- Albumin; globulin; creatinine in mg/dL(Up to 24 weeks)
- Aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase and creatine kinase in U/L(Up to 24 weeks)
Investigators
Bruno Gualano
Principal Investigator
University of Sao Paulo