Metabolomics Characterization of Biomarkers of Different Types of Myocardial Infarction in Different Time.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- metabolites molecules
研究概览
简要总结
To find new biomarkers through Metabonomics Study of different types of myocardial infarction in Different Time.
详细描述
In recent years, with the deepening understanding of the mechanism of myocardial infarction, in addition to the early understanding of plaque rupture, plaque erosion and other mechanisms, studies have found that inflammation, immunity, metabolism and other factors also play an increasingly important role in the occurrence and development of myocardial infarction. The LoDoCo2 study published at the 2020 ESC annual meeting and the COLCOT study previously published confirmed for the first time the therapeutic effect of anti-inflammatory drug colchicine in chronic coronary disease and acute myocardial infarction. At the same time, the fourth international definition of myocardial infarction also defines three different types of acute ST segment elevation myocardial infarction (STEMI), acute non ST segment elevation myocardial infarction (NSTEMI) and non infarct acute myocardial infarction (MINOCA). However, there are no clear research results on the mechanism, especially the mechanism of MINOCA. Therefore, the study of acute myocardial infarction in three groups is of great significance.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 76 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •1.The patient clearly had acute myocardial infarction. 2.The patient's serum cardiac markers (mainly troponin) were elevated (at least above the upper limit of 99% reference value) and accompanied by one of the following clinical indicators：
- •Ischemic symptoms
- •New ischemic ECG changes, new ST-T changes or left bundle branch block（LBBB）.
- •Pathological Q wave formation in ECG
- •Imaging evidence showed new loss of myocardial activity or new regional wall motion abnormalities.
- •The thrombus was confirmed by coronary angiography. 3．The patient had chest pain symptoms, but coronary angiography showed normal coronary artery (such as intercostal neuralgia, cervical spondylosis, chest pain of unknown origin, etc.)
排除标准
- •Refusal to sign informed consent.
- •Surgical treatment was performed in the last three months.
- •Patients with a history of the following diseases or consider the diagnosis of the following diseases：Stress cardiomyopathy, myocarditis, pericarditis, pneumonia, pulmonary embolism, aortic dissection.
- •Severe heart failure, grade IV cardiac function.
- •Liver and kidney dysfunction.
- •blood-borne diseases, including HIV / AIDS, hepatitis B, hepatitis C, etc.
- •Patients with a history of malignancies, autoimmune diseases, severe infectious diseases and trauma.
- •Previous history of myocardial infarction and stroke.
结局指标
主要结局
metabolites molecules
时间窗: 6 months
Detection of small molecular metabolites in blood by liquid chromatography mass spectrometry and gas chromatography mass spectrometry
次要结局
未报告次要终点
研究者
Ya-Wei Xu
cardiology department of shanghai 10th people's hospital
Shanghai 10th People's Hospital