Cognitive Control Training for Remitted Depressed Patients

Not Applicable

Completed

• Conditions: Major Depression in Remission
• Interventions: Behavioral: Cognitive Control Training; Behavioral: Low Cognitive Load Training

• Registration Number: NCT02407652
• Lead Sponsor: University Ghent

Brief Summary

The purpose of this study is to explore the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.

Detailed Description

Prospective studies have linked impaired cognitive control to increased cognitive vulnerability for future depression. Importantly, experimental studies indicate that cognitive control training can be used to reduce rumination and depressive symptomatology in MDD samples. Furthermore, studies exploring the potential of cognitive control training in at-risk undergraduate students indicate that cognitive control training has beneficial effects on rumination, an important vulnerability factor for depression. Provided that remitted depressed patients form a high-risk group for developing future depressive episodes, the current study will explore whether internet-delivered cognitive control training can be used to reduce vulnerability for future depression in remitted depressed patients. The investigators will explore effects on depressive symptomatology, (mal-)adaptive emotion regulation (directly following training and at 3 months follow-up), and indices of functioning (at 3 months follow-up).

Study Timeline

• Study Start: 2014-12
• Study First Submitted: 2015-03-10
• Study First Submitted QC: 2015-04-02
• Study First Posted: 2015-04-03
• Primary Completion: 2015-10
• Study Completion: 2015-10
• Status Verified: 2015-12
• Last Update Submitted: 2015-12-16
• Last Update Posted: 2015-12-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

• History of ≥ 1 depressive episode(s)
• Currently in stable full or partial remission (≥ 6 months)

Exclusion Criteria

• Major depressive disorder (MDD; current)
• Bipolar disorder (current and/or previous)
• Psychotic disorder (current and/or previous)
• Neurological impairments (current and/or previous)
• Excessive substance abuse (current and/or previous)
• No other comorbid disorders (current)
• No ongoing psychotherapeutic treatment (maintenance treatment is allowed, but with a frequency less than once / 3 weeks)
• Use of antidepressant medication is allowed if kept at a constant level

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
cognitive control training	Cognitive Control Training	internet-delivered, 2 weeks
low cognitive load training	Low Cognitive Load Training	internet-delivered, 2 weeks

Primary Outcome Measures

Name	Time	Method
Change in depressive rumination from baseline to the post-training assessment and follow-up (RRS)	baseline, 2 weeks, 3 months	Assessed using the Ruminative Response Scale (RRS)
Change in depressive symptomatology from baseline to the post-training assessment and follow-up (BDI-II)	baseline, 2 weeks, 3 months	Assessed using the Beck Depression Inventory (BDI-II)

Secondary Outcome Measures

Name	Time	Method
Resilience (RS)	baseline, 3 months	Assessed using the Resilience Scale (RS)
Quality of Life (QLDS)	baseline, 3 months	Assessed using the Quality of Life in Depression Scale (QLDS)
Disability (WHODAS 2.0)	baseline, 3 months	Assessed using the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0)
(mal-)Adaptive cognitive emotion regulation (CERQ)	baseline, 2 weeks, 3 months	Assessed using the Cognitive Emotion Regulation Questionnaire (CERQ)
Remission from depression (RDQ)	baseline, 3 months	Assessed using the Remission of Depression Questionnaire (RDQ)

Trial Locations

Locations (1)

Ghent University; 🇧🇪 Ghent, Oost-Vlaanderen, Belgium