Cognitive Control Training as a Preventive Intervention for Depression: A Double-blind Randomized Controlled Trial Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University Ghent
- Enrollment
- 68
- Locations
- 2
- Primary Endpoint
- Change in depressive rumination from baseline to the post-training assessment and follow-up (RRS)
Study Overview
Brief Summary
The purpose of this study is to explore the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.
Detailed Description
Prospective studies have linked impaired cognitive control to increased cognitive vulnerability for future depression. Importantly, experimental studies indicate that cognitive control training can be used to reduce rumination and depressive symptomatology in MDD samples. Furthermore, studies exploring the potential of cognitive control training in at-risk undergraduate students indicate that cognitive control training has beneficial effects on rumination, an important vulnerability factor for depression. Provided that remitted depressed patients form a high-risk group for developing future depressive episodes, the current study will explore whether internet-delivered cognitive control training can be used to reduce vulnerability for future depression in remitted depressed patients. The investigators will explore effects on depressive symptomatology, (mal-)adaptive emotion regulation (directly following training and at 3 months follow-up), and indices of functioning (at 3 months follow-up).
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 23 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •History of ≥ 1 depressive episode(s)
- •Currently in stable full or partial remission (≥ 6 months)
Exclusion Criteria
- •Major depressive disorder (MDD; current)
- •Bipolar disorder (current and/or previous)
- •Psychotic disorder (current and/or previous)
- •Neurological impairments (current and/or previous)
- •Excessive substance abuse (current and/or previous)
- •No other comorbid disorders (current)
- •No ongoing psychotherapeutic treatment (maintenance treatment is allowed, but with a frequency less than once / 3 weeks)
- •Use of antidepressant medication is allowed if kept at a constant level
Outcomes
Primary Outcomes
Change in depressive rumination from baseline to the post-training assessment and follow-up (RRS)
Time Frame: baseline, 2 weeks, 3 months
Assessed using the Ruminative Response Scale (RRS)
Change in depressive symptomatology from baseline to the post-training assessment and follow-up (BDI-II)
Time Frame: baseline, 2 weeks, 3 months
Assessed using the Beck Depression Inventory (BDI-II)
Secondary Outcomes
- Resilience (RS)(baseline, 3 months)
- Quality of Life (QLDS)(baseline, 3 months)
- Disability (WHODAS 2.0)(baseline, 3 months)
- (mal-)Adaptive cognitive emotion regulation (CERQ)(baseline, 2 weeks, 3 months)
- Remission from depression (RDQ)(baseline, 3 months)