Online Cognitive Control Training for Remitted Depressed Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 68
- 试验地点
- 2
- 主要终点
- Change in depressive symptomatology
研究概览
简要总结
This study evaluates the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients. Half of the participants will receive a cognitive control training, while the other half will receive a low cognitive load training that acts as an active control condition.
详细描述
Prospective studies have linked impaired cognitive control to increased cognitive vulnerability for future depression. Importantly, experimental studies indicate that cognitive control training can be used to reduce rumination and depressive symptomatology in MDD (major depressive disorder) and RMD (remitted depressed) samples. Provided that remitted depressed patients form a high-risk group for developing future depressive episodes, the current study will explore whether an internet-delivered cognitive control training can be used to reduce vulnerability for future depression in remitted depressed patients.
A computer training, consisting of 10 sessions of 15 minutes each, will be administered to participants, which are remitted depressed patients. This training can either be a cognitive control training, using an adaptive paced auditory serial addition task, or an active control training, with a low cognitive load task.
Dependent variables will be assessed pre- and post-training, as well as 3 and 6 months after the training, and consist of depressive symptomatology, related variables and cognitive control measures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •History of ≥ 1 depressive episodes (major or bipolar)
- •Currently in stable full or partial remission (≥ 3 months)
排除标准
- •Major depressive disorder (current or less than 3 months in remission)
- •Bipolar disorder (current or less than 3 months in remission)
- •Psychotic disorder (current and/or previous)
- •Neurological impairments (current and/or previous)
- •Excessive substance abuse (current and/or previous)
- •No ongoing psychotherapeutic treatment (maintenance treatment is allowed, but with a frequency of less than once every three weeks)
- •Use of antidepressant medication is allowed if kept at a constant level
结局指标
主要结局
Change in depressive symptomatology
时间窗: Assessed at pre-training assessment, at post-training assessment (within 1 week of completing the training), at 3 months follow-up and at 6 months follow-up
Measured by the Depression Anxiety Stress Scales (DASS)
Change in depressive rumination (brooding)
时间窗: Assessed at pre- and post-training assessment (within 1 week of completing the training) and at 3 and 6 months follow-up
Measured by the Ruminative Response Scale (RRS), especially the brooding subscale
次要结局
- Change in cognitive emotion regulation strategies(Assessed at pre- and post-training assessment (within 1 week of completing the training) and at 3 and 6 months follow-up)
- Resilience(Assessed at pre- and post-training assessment (within 1 week of completing the training) and at 3 and 6 months follow-up)
- Change in quality of life(Assessed at pre- and post-training assessment (within 1 week of completing the training) and at 3 and 6 months follow-up)
- Remission from depression(Assessed at pre- and post-training assessment (within 1 week of completing the training) and at 3 and 6 months follow-up)