The effect of joint acupuncture and traditional Chinese medicine pretreatment on the high qualified embryo rate of elderly renal deficiency DOR women undergoing IVF/ ICSI- ET and the regulation on the cervicovaginal microbiome and local immune response: a prospective open-label randomized controlled trial
- Conditions
- Infertility
- Registration Number
- ITMCTR2000003569
- Lead Sponsor
- Tongji Hospital Affiliated to Tongji University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- Not specified
1. Aged between 35 and 42 years old;
2. conforms to the indications for IVF/ICSI-ET;
3. conforms to the diagnostic criteria of DOR;
4. conforms to the diagnostic criteria of renal deficiency syndrome in Chinese medicine;
5. The main causes of infertility are fallopian tube factors, and exclude hypothalamus and other endocrine diseases(hypothyroidism or hyperthyroidism, diabetes, etc.), polycystic ovary syndrome (PCOS), severe pelvic endometriosis, adenomyosis, etc.;
6. Patients agree to participate in this clinical study and sign an informed consent form.
1. Within 3 months, there was a history of steroid hormone treatment and a history of uterine operation;
2. It has been clear that there are obvious and serious other organic lesions in the reproductive organs;
3. With ovarian premature failure, previous ovarian surgery history and only single ovarian;
4. PCOS, adenomyosis, uterine malformations, chromosomal abnormalities, ovarian tumors, and other endocrine diseases(diabetes, thyroid dysfunction, etc.);
5. Hereditary diseases that are not suitable for production, and are currently not capable of being diagnosed by preimplantation genetics under the Maternal and Child Health Act;
6. The couple merged with Severe primary diseases of the cardiovascular, hepatic, renal or hematopoietic systems , or with mental illness;
7. Either of the couple has serious addictions such as drug use and exposure to teratogenic rays, poisons, and drugs and is in the action period;
8. Allergic constitution and allergy to many drugs;
9. Can not insist on treatment.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method