Comparison of Peripheral and Central Intubation on Hemodynamics in Veno-arterial-extracorporeal Membrane Oxygenation (RECOVERY): a National, Multi-center, Prospective, Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 136
- 试验地点
- 1
- 主要终点
- Left ventricular end-diastolic volume (ml)
研究概览
简要总结
The goal of this clinical trial is to monitor hemodynamic differences between central veno-arterial extracorporeal membrane oxygenation (VA ECMO) and peripheral VA ECMO. The main question it aims to answer is:
- Efficacy of the different cannulation strategies for the establishment of for VA-ECMO circulation on hemodynamics and organ perfusion.
Participants require VA ECMO support, will be divided into two groups in an intention-to-treat analysis: central artery cannulation and peripheral artery cannulation.
Researchers will analyze different cannulation strategies for VA-ECMO and identify potential advantages and disadvantages for two groups of VA-ECMO.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age≥18 years
- •Participants with cardiogenic shock
- •Obtaining informed consent from participants or their affiliated beneficiaries
排除标准
- •Irreversible heart failure
- •Contraindications to anticoagulation therapy
- •Uncontrolled bleeding
- •Irreversible neurological pathology
- •Participants limited to extracorporeal cardiopulmonary resuscitation
结局指标
主要结局
Left ventricular end-diastolic volume (ml)
时间窗: Through VA ECMO support completion, an average of 1 week
echocardiography
Mitral valve area(cm2)
时间窗: Through VA ECMO support completion, an average of 1 week
echocardiography
Oxygen saturation-no. (%)
时间窗: Through VA ECMO support completion, an average of 1 week
Blood gas analysis
Left ventricular End-systolic volume (ml)
时间窗: Through VA ECMO support completion, an average of 1 week
echocardiography
Stroke volume (ml)
时间窗: Through VA ECMO support completion, an average of 1 week
echocardiography
次要结局
- Duration of ICU stay(Through study completion, up to 2 years)
- Duration of hospital stay(Through study completion, up to 2 years)
- VA ECMO duration(Through VA ECMO support, an average of 1 week)
- Cannulation-related complications(Through study completion, up to 2 years)
- Rate of successful weaning from VA ECMO(Through study completion, up to 2 years)