Ischemic Strokes While on NOAC - How Compliance Matters

Recruiting

• Conditions: Stroke, Acute; Ischemic Stroke; Stroke, Cardiovascular; Atherosclerosis; Stroke, Ischemic; Stroke Syndrome

• Registration Number: NCT04607070
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

This study is aimed to depict the epidemiological trend, aetiologies, clinical characteristics, treatment options of IS-NOAC in face of the rapidly increasing NOAC usage. Knowledge on this ischaemic stroke entity will define clinical characteristics, identify preventable causes and inform resource allocation on the evaluation modalities, reperfusion strategies and forecast future burden of IS-NOAC.

Detailed Description

Data will be retrieved from the stroke registry of Prince of Wales Hospital which recorded all in- and out-patients with stroke or transient ischaemic attack (TIA). All consecutive adult patients with known AF who developed ischaemic stroke or TIA in 2010, 2012, 2014, 2016 and 2018 (i.e. 5 full yearly time-points) and categorize the patients according to their anticoagulation status (elaborated below) with the inclusion and exclusion criteria stated will be recruited.

All demographic data, blood results, imaging and assessment data will be retrieved from electronic patient record (CMS system) and stroke registry. All-cause mortality at 1 year will be verified via CMS system too.

Study Timeline

• Study Start: 2020-10-01
• Study First Submitted: 2020-10-23
• Study First Submitted QC: 2020-10-23
• Study First Posted: 2020-10-28
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-27
• Last Update Posted: 2025-01-29
• Primary Completion: 2025-09-30
• Study Completion: 2026-03-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 870

Inclusion Criteria

1. Patients who were ethnic Chinese
2. Patients with known AF
3. Patient who suffered from ischaemic stroke

Exclusion Criteria

1. Patient who are non-ethnic Chinese
2. Patient who suffered from haemorrhagic stroke

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Compliance affects the outcomes of ischemic stroke during NOAC usage.	30 Sept 2021	To depict epidemiological trend and aetiologies on different dosage of NOAC in stroke patients.

Trial Locations

Locations (1)

Chinese University of Hong Kong; 🇭🇰 Hong Kong, Hong Kong