NCT06081738进行中（未招募）4 期
Evaluation of The Effects of Neostigmine Versus Sugammadex on Renal Functions in Laparoscopic Cholecystecomy A Randomized Controlled Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 进行中（未招募）
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- neutrophil gelatinase associated lipocalin (NGAL) values
研究概览
简要总结
The study will assess the acute effects of sugammadex or neostigmine on renal function as determined with more specific and sensitive tests in laparoscopic cholecystectomy
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •normal renal function (serum Cr 0.4- 1.4 g/dL)
- •American Society of Anesthesiologists (ASA) Class I-II
排除标准
- •Incapacity to consent.
- •Pre-existing impaired kidney functions.
- •Severe neuromuscular disease, as: myasthenia gravis & muscular dystrophy.
- •Intra-operative bleeding
- •Lengthy operations that exceed 2 hours.
- •Hemodynamic changes more than 20% of the base line
研究组 & 干预措施
Neostigmine Group
Active Comparator
干预措施: Neostigmine (Drug)
Sugammadex Group
Active Comparator
干预措施: Sugammadex (Drug)
结局指标
主要结局
neutrophil gelatinase associated lipocalin (NGAL) values
时间窗: baseline ( 2 days preoperative) and 12 hours after surgery
normal overall unisex value 47-55 ng/ml
次要结局
未报告次要终点
研究者
mostafa saieed fahim mansour
lecturer
Menoufia University
研究点 (1)
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