Neostigmine Versus Sugammadex on Renal Functions
Phase 4
Active, not recruiting
- Conditions
- SugammadexNeostigmine
- Interventions
- Registration Number
- NCT06081738
- Lead Sponsor
- Menoufia University
- Brief Summary
The study will assess the acute effects of sugammadex or neostigmine on renal function as determined with more specific and sensitive tests in laparoscopic cholecystectomy
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 64
Inclusion Criteria
- normal renal function (serum Cr 0.4- 1.4 g/dL)
- American Society of Anesthesiologists (ASA) Class I-II
Exclusion Criteria
- Incapacity to consent.
- Pre-existing impaired kidney functions.
- Severe neuromuscular disease, as: myasthenia gravis & muscular dystrophy.
- Intra-operative bleeding
- Lengthy operations that exceed 2 hours.
- Hemodynamic changes more than 20% of the base line
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Sugammadex Group Sugammadex - Neostigmine Group Neostigmine -
- Primary Outcome Measures
Name Time Method neutrophil gelatinase associated lipocalin (NGAL) values baseline ( 2 days preoperative) and 12 hours after surgery normal overall unisex value 47-55 ng/ml
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie neostigmine and sugammadex effects on renal function in laparoscopic cholecystectomy?
How does sugammadex compare to neostigmine in preserving renal function as standard-of-care reversal agents in laparoscopic surgery?
Are there specific biomarkers that predict differential renal response to neostigmine versus sugammadex in surgical patients?
What adverse renal events are associated with neostigmine use compared to sugammadex in phase 4 clinical trials for laparoscopic procedures?
How do neostigmine and sugammadex interact with cholinergic receptors in the context of laparoscopic cholecystectomy and renal function preservation?
Trial Locations
- Locations (1)
Menoufia University Hospitals
🇪🇬Shibīn Al Kawm, Menoufia, Egypt
Menoufia University Hospitals🇪🇬Shibīn Al Kawm, Menoufia, Egypt