The mechanism study of Taijiquan training releasing circulatory exosomes to promote the remodeling of cognitive neural circuits

Fujian University of Traditional Chinese Medicine0 个研究点开始时间: 待定最近更新: 2023年2月20日

试验速览

暂无简介。

•(1)Long-term regular Tai Chi exercise group:
•? Gender is not limited, and the age range from 60 to 75 years old;
•? At least 6 years of education;
•? Long-term regular Tai Chi exercise for at least 6 years, 3 time per week, and more than 30min each time;
•? Right-handed;
•? Normal cognitive function (MoCA scale score = 26 points);
•? Subjects are informed and volunteer to sign informed consent.
•(2)Long-term no exercise group:
•?Gender is not limited, the age range from 60 to 75 years old, and the proportion matches the age, gender and education level of the long-term regular Tai Chi group;
•? At least 6 years of education;
•? At least 6 years of irregular physical exercise (such as traditional sports, jogging, yoga, meditation, brisk walking, etc.), exercise < 3 times a week, and each session < 30 minutes;
•? Right-handed;
•? Normal cognitive function (MoCA scale score = 26 points);
•? Subjects are informed and volunteer to sign informed consent.

•? Have neurological diseases (such as stroke, Parkinson's, epilepsy or dementia), history of mental illness, history of traumatic brain injury, history of brain mass, etc.;
•? Those with uncontrollable hypertension (systolic blood pressure =160mmHg or diastolic blood pressure =100mmHg after taking the drug), and those with diabetes mellitus (HbA1c>8%);
•? Are taking or have taken drugs that affect the nervous system or psychosis within 2 weeks
•? Depressed patients, the geriatric depression scale> 5 points;
•? Patients with implanted metal substances (such as metal dentures, pacemakers, etc.), space claustrophobia and other patients who are not suitable for MRI;
•? Those who have visual/hearing impairment or writing/reading impairment that cannot cooperate to complete the assessment;
•? Those who are participating in other research trials that affect the results of this research.

发起方

Fujian University of Traditional Chinese Medicine