Clinical study of taijiquan training combined with repetitive transcranial magnetic stimulation on depressive symptoms in young patients with subthreshold depressio

Early Phase 1

• Conditions: subthreshold depression

• Registration Number: ITMCTR2024000160
• Lead Sponsor: The Third People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1) Age 19 to 30 years old, gender is not limited;
2) The Center for Epidemiologic Studies Depression Scale (CES-D) score between 16 and 25;
3) Right-handedness;
4) Informed consent and voluntary participation.

Exclusion Criteria

1) Satisfaction of diagnostic criteria for mood disorders, bipolar depressive disorder, psychosis, etc. according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) diagnostic criteria;
2) Previous history of major depression, epilepsy or family history of epilepsy, neurodegenerative disease, cerebrovascular disease, neurological disease, history of brain injury, etc;
3) Prior use of psychiatric medications or addiction disorders (e.g., drug abuse, alcoholism, etc.);
4) Presence of metal implants in the body, such as pacemakers, cochlear implants, metal joints, and other ferromagnetic foreign objects, high fever, pregnancy, claustrophobia, and other contraindications to MRI scanning;
5) Patients with severe sleep disorders or severe anxiety disorders. The insomnia severity index (ISI) =22, Hamilton Anxiety Scale (HAMA) score =29;
6) Those who are participating in other clinical trials that affect the evaluation of the results of this study.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patient Health Questionnaire, PHQ-9;

Secondary Outcome Measures

Name	Time	Method
Perceived Stress Scale, PSS;Medical Outcomes Study 36-Item Short-Form Health Survey,SF-36;Hamilton Depression Scale,HAMD;Generalized Anxiety Disorder,GAD-7;Snaith-Hamilton pleasure scale, SHAPS;Magnetic Resonance Image;Chinese Affective Scale, CAS;Pittsburgh Sleep Quality Index,PSQI;