Aerobic Exercise on Ventilatory Efficiency in CAD Patients

Phase 2

Completed

• Conditions: Coronary Artery Disease; Exercise Addiction; Complication, Cardio-respiratory
• Interventions: Other: Aerobic exercise training

• Registration Number: NCT02106533
• Lead Sponsor: Hospital TotalCor

Brief Summary

The purpose of the present study was to test the hypothesis that patients with coronary artery disease with lower aerobic fitness exhibit greater responsiveness on improving ventilatory efficiency after aerobic exercise training.

Detailed Description

Measurements of ventilatory efficiency during cardiorespiratory exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs. In addition, a growing body of studies has demonstrated that lower ventilatory efficiency during exercise is considered an important predictor of risk mortality, hospitalization, and other outcomes than peak VO2.

Study Timeline

• Study Start: 2011-08
• Primary Completion: 2012-06
• Study Completion: 2013-05
• Study First Submitted: 2014-03-27
• Status Verified: 2014-04
• Study First Submitted QC: 2014-04-07
• Last Update Submitted: 2014-04-07
• Study First Posted: 2014-04-08
• Last Update Posted: 2014-04-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 123

Inclusion Criteria

• was stable coronary artery disease diagnosed by coronary angiography

Exclusion Criteria

• unstable angina pectoris,
• complex ventricular arrhythmias,
• pulmonary congestion and
• orthopaedic or neurological limitations to exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group 1 peak VO2 <17.5 ml/kg/min	Aerobic exercise training	The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill and 5 minutes of cool-down exercises. Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP.
Group 2 peak VO2 > 17.5 < 24.5 ml/kg/min	Aerobic exercise training	The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill and 5 minutes of cool-down exercises. Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP. All patients were able to achieve the set aerobic training intensity.
Group 3 peak VO2 > 24.5 ml/kg/min	Aerobic exercise training	The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill . Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP. All patients were able to achieve the set aerobic training intensity.

Primary Outcome Measures

Name	Time	Method
Ventilatory efficiency in patients with coronary artery disease	up to 3 months of the interventions	Measurements of ventilatory efficiency during cardiopulmonary exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs.