The Effects of Aerobic Exercise in Microvascular Endothelium Function in Patients With Cardiovascular Diseases

Completed

• Conditions: Cardiovascular Diseases
• Interventions: Behavioral: Exercise

• Registration Number: NCT02514564
• Lead Sponsor: Instituto Nacional de Cardiologia de Laranjeiras

Brief Summary

This study evaluates the effects of different volumes of aerobic exercise training in cardiovascular parameters of patients with cardiovascular diseases enrolled in a cardiac rehabilitation program.

Detailed Description

Aerobic exercise training is well known to improve endothelium dependent vasodilatation in the microcirculation. However, the impact of exercise frequency on this response in patients with coronary artery disease remains unclear.

Study Timeline

• Study Start: 2014-12
• Study First Submitted: 2015-07-30
• Study First Submitted QC: 2015-07-30
• Study First Posted: 2015-08-03
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Status Verified: 2017-03
• Last Update Submitted: 2017-03-01
• Last Update Posted: 2017-03-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

• sedentarism for at least 6 months;
• clinical diagnosis for coronary artery disease (occurrence of any acute coronary syndrome, including ST elevation or non-ST elevation myocardial infarction or unstable angina or by the diagnosis of obstructive coronary artery disease on coronary angiography in patients with stable angina).

Exclusion Criteria

• nephropathies;
• decompensated cardiovascular diseases;
• liver diseases.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
3x/wk	Exercise	This group will be consisted of patients that will perform exercise three times a week.
2x/wk	Exercise	This group will be consisted of patients that will perform exercise two times a week.

Primary Outcome Measures

Name	Time	Method
Changes in Skin microvascular blood flow	Change from baseline in skin microvascular blood flow at 6 months	Measured through a Laser Speckle Contrast Imaging equipment

Secondary Outcome Measures

Name	Time	Method
Change in weight	Change from baseline in weight at 6 months	Measured with a calibrated digital scale
Change in peak oxygen consumption	Change from baseline in peak oxygen consumption at 6 months	Measured at a maximal graded exercise test

Trial Locations

Locations (1)

Instituto Nacional de Cardiologia; 🇧🇷 Rio de Janeiro, RJ, Brazil