PROactive Management Of Depression in the Elderly

Completed

• Conditions: Depressive symptoms; Mental and Behavioural Disorders; Depression

• Registration Number: ISRCTN71142851
• Lead Sponsor: eiden University Medical Center (LUMC) (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01-16
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 4000

Inclusion Criteria

1. Inclusion criteria for screening: elderly aged 75 years and over enlisted in general practices
2. Inclusion criteria for treatment-offer: screen positive for depression (Geriatric Depression Scale [GDS-15] more than four)

Exclusion Criteria

1. Exclusion criteria for screening: terminal illness, current treatment for depression, loss of partner/important relative within previous three months
2. Exclusion criteria for treatment-offer: severe cognitive impairment (Mini Mental State Examination [MMSE] less than 19)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in severity of depressive symptoms (Montgomery Asberg Depression Rating Scale [MADRS] baseline - six months).

Secondary Outcome Measures

Name	Time	Method
Differences (at six and 12 months) in: <br>1. Percentage responders to treatment<br>2. Quality of life (Short Form health survey [SF-36], EuroQol questionnaire [EQ-5D])<br>3. Mortality<br>4. Use of (in)formal help or home care<br>5. Medical consumption<br>6. Cost-effectiveness<br>7. Costs per Quality Adjusted Life Year (QALY)