Detection of acute kidney injury in intensive care units using novel urine test.

Not yet recruiting

Conditions: Medical and Surgical,

Registration Number: CTRI/2020/02/023319

Lead Sponsor: BioMerieux India Pvt Ltd

Brief Summary: Acute Kidney Injury (AKI) is a complex disorder encountered from 5% in hospitalized patients and 40-60% in ICU setting. it is associated with high mortality and increased resource utilization . Clinical trials have demonstrated the efficacy of these new biomarkers in detecting kidney damage, predicting disease progression and determining potential recovery. Two Randomized clinical trials have shown the efficacy of TIMP2 and IGFBP biomarkers in Cardiac surgery (PREVAKI)2 and high risk surgery patients (BIGPAK)3 to improve outcomes. Unfortunately the adoption of damage biomarkers into routine clinical care worldwide has been limited. In This study we propose to characterize the utility of nephrocheck in the diagnosis, differentiation and management of AKI in patients with sepsis and major surgery in the ICU across multiple centers in india provide new information on patterns of AKI development, course and management and ascertain the barriers to boimarker applications in this setting. The data obtained will inform the development of best practices for optimal utilization of the nephrocheck markers to improve outcomes from AKI.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 1000

Inclusion Criteria

Age > 18 admitted to ICUs Diagnosis of sepsis or following major surgery.
High risk of developing AKI based on the Malhotra score > 88.

Exclusion Criteria

Unable to give consent and absence of any surrogate to give consent Chronic hemodialysis or peritoneal dialysis within the past 12 months Functioning kidney transplantation Patients not expected to survive more than 48 h Prisoners.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Development of acute kidney injury.	Day 7 after enrollment.

Secondary Outcome Measures

Name	Time	Method
1.Requirement of dialysis.	2.length of hospital and ICU stay.

Trial Locations

Locations (11): ILS Hospital
🇮🇳
Kolkata, WEST BENGAL, India
Apollo Hospitals
🇮🇳
Hyderabad, TELANGANA, India
J. S. S. Medical college hospital
🇮🇳
Mysore, KARNATAKA, India
JIPMER
🇮🇳
Pondicherry, PONDICHERRY, India
KEM Hospital, Pune
🇮🇳
Pune, MAHARASHTRA, India
Medanta Medicity Hospital
🇮🇳
Delhi, DELHI, India
PIGMER
🇮🇳
Chandigarh, CHANDIGARH, India
Sanjay Gandhi Postgraduate Institute of Medical Sciences
🇮🇳
Lucknow, UTTAR PRADESH, India
Santokba Durlabhji Memorial Hospital
🇮🇳
Jaipur, RAJASTHAN, India
Star Hospitals
🇮🇳
Hyderabad, TELANGANA, India
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ILS Hospital
🇮🇳Kolkata, WEST BENGAL, India
Dr Prathim Senugupta
Principal investigator
9830159686
pratim.sengupta@gmail.com