A Study to Assess the Changes in Bone Around Cementless Knee Replacements

Not Applicable

Completed

• Conditions: Knee osteoarthritis; Musculoskeletal - Osteoarthritis

• Registration Number: ACTRN12618001618246
• Lead Sponsor: Professor Gary Hooper

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-06-01
• Study Start: 2018-10-02
• Last Update Posted: 10 February 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 89

Inclusion Criteria

1.Adult (>30 years) males and females with anteromedial unicompartmental knee osteoarthritis.
2.Sufficient bone quality to allow insertion of a uni knee prosthesis.
3. Scheduled to undergo an Oxford cementless uni-compartmental knee replacement
3.Patello-femoral osteoarthritis is not a contraindication if person does not have symptoms from the patello-femoral joint.
4.Able to provide informed consent.
5.In good general health.

Exclusion Criteria

1. Neuromuscular or vascular disease in the affected leg
2. Found to be unsuitable for uncemented unicompartmental Oxford knee replacement before or at surgery
3. Preoperative extensions defect greater than 15 degrees
4. Preoperative maximal flexion of less than 100 degrees
5. Symptomatic patello-femoral osteoarthritis
6. Insufficiency of the anterior-cruciate ligament
7. Fracture sequelae (intraarticular fracture and all tibial condyle fractures)
8. Previous osteotomy
9. Previous extensive knee surgery
10. Metabolic bone disease
11. Rheumatoid arthritis
12. Postmenopausal women on systemic hormone replacement therapy
13. Long-term treatment with oral corticosteroids
14. Inability to give consent (such as history of Alzheimers disease)
15. History of misuse of drugs or alcohol
16. Serious psychiatric disease
17. Disseminated malignant disease and treatment with radiotherapy or chemotherapy
18. Serious systemic disease
19. Inability to complete the questionnaires in English
20. Women of childbearing age who are pregnant or who have not had a negative pregnancy test just prior to the examination
21. Orthopaedic deformity that prevents an iDXA scan of either knee

Study & Design

• Study Type: Observational
• Study Design: Not specified