Maternal and Neonatal Outcome in Severe Preeclampsia

• Conditions: Pre-Eclampsia

• Registration Number: NCT04126122
• Lead Sponsor: Aljazeera Hospital

Brief Summary

In normal pregnancy the spiral arteries in the placental bed are invaded by trophoblast, which becomes incorporated into the vessel wall and replaces the endothelium, muscular layer and neural tissue

Detailed Description

Preeclampsia is considered severe if one or more of the following:

1. Blood pressure of 160mmHg systolic or high or 110mmHg diastolic or high on two occasions at least 6 hours a part while the patient on bed rest.

2. Proteinuria of 0.3gm. or high in 24 hours urine specimen or +1 or great on two random urine samples collected at least 4 hours apart.

3. Oliguria of less than 500ml in 24 hours.

4. Cerebral or visual disturbance.

5. Pulmonary edema or cyanosis.

Study Timeline

• Study Start: 2019-02-10
• Status Verified: 2019-10
• Study First Submitted: 2019-10-11
• Study First Submitted QC: 2019-10-11
• Last Update Submitted: 2019-10-11
• Study First Posted: 2019-10-15
• Last Update Posted: 2019-10-15
• Primary Completion: 2020-01-10
• Study Completion: 2020-02-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• • All women with severe preeclampsia

Exclusion Criteria

• • History of epilepsy.

  • Patients with chronic hypertension.
  • Patients with renal disease.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The number of women who will develop adverse outcome	within 5 months	The women with preeclampsia who will develop eclampsia or pulmonaryb edema

Trial Locations

Locations (1)

Aljazeera( Al Gazeera) hospital; 🇪🇬 Giza, Egypt