Respiratory Function and Walking Capacity in Multiple Sclerosis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 50
- Primary Endpoint
- Respiratory muscle strength
Study Overview
Brief Summary
Multiple sclerosis (MS) is a chronic progressive neurological disease. Respiratory dysfunction due to weakness in the respiratory musculature has been described in MS. This leads to increased morbidity and mortality in late stages of the disease. It is possible that respiratory dysfunction influence physical fitness in earlier stages as well. Walking disability and fatigue causes significant impact on health in patients with MS, even in earlier stages.
The hypothesis is that there is a relationship between respiratory function, walking capacity and fatigue and that daily deep breathing exercise during two months will improve respiratory function, walking capacity and fatigue.
Detailed Description
Presented above.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Investigator)
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Inhabitant in Orebro county, Sweden, that are diagnosed with MS according to the revised McDonald criteria and registered in the Swedish MS-registry with EDSS (Expanded disability status scale) score in the interval ≥ 3.0 - ≤ 7.
- •Participants must understand verbal and written information and must be relapse free ≥ 3 months prior to inclusion.
Exclusion Criteria
- •Patients with diseases that may have influence on walking ability and respiratory function (other than MS). Such conditions include heart and lung diseases, orthopedic disorders, patients recently subjected to surgery, and non-MS related neurological dysfunction.
Arms & Interventions
Breathing exercises
Daily deep breathing exercises during two month
Intervention: Breathing exercises (Other)
Control
Control group
Outcomes
Primary Outcomes
Respiratory muscle strength
Time Frame: Two months
Maximum expiratory pressure
Secondary Outcomes
No secondary outcomes reported
Investigators
Anna Wittrin
Phd
Region Örebro County