Minimally Invasive Radioguided Parathyroidectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 856
- 试验地点
- 1
- 主要终点
- The positive and negative predictive value of sestamibi scanning to detect parathyroid adenomas.
研究概览
简要总结
The main purpose of this research study is to evaluate the effectiveness of a minimally invasive surgical approach to removing parathyroid gland(s). The researchers are also interested in analyzing abnormal parathyroid tissue for changes in genes and proteins that may contribute to overactive parathyroid gland(s).
详细描述
The specific aims of this study are to determine the safety and efficacy of minimally invasive radioguided parathyroidectomy, to determine the positive and negative predictive value of sestamibi scanning to detect parathyroid adenomas, and to differentiate adenomas from parathyroid hyperplasia. In addition, this study aims to determine the value of intraoperative parathyroid hormone assay to verify biochemical cure of primary hyperparathyroidism, to determine whether minimally invasive radioguided parathyroidectomy is cos-effective, and to collect abnormal parathyroid tissue at the time of surgery for tissue analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with biochemical evidence of primary hyperparathyroidism
排除标准
- 未提供
结局指标
主要结局
The positive and negative predictive value of sestamibi scanning to detect parathyroid adenomas.
时间窗: 2-3days
次要结局
- Collection of abnormal parathyroid tissue at the time of surgery for tissue analysis(day of surgery (1 day))
- The value of intraoperative parathyroid hormone assay to verify biochemical cure or primary hyperparathyroidism(2-3 days)
研究者
Michael B. Flynn, MD
Professor
University of Louisville