Effect of Helicobacter Pylori Treatment on Idiopathic Central Serous Chorioretinopathy (ICSCR)

Phase 1

Completed

• Conditions: Central Serous Chorioretinopathy
• Interventions: Drug: omeprazole, Amoxicillin, metronidazole

• Registration Number: NCT00817245
• Lead Sponsor: Tabriz University

Brief Summary

Etiology of ICSCR is not known however recent studies regard the role of immunologic and infectious processes in the pathogenesis of ICSCR.one of these hypothesis is the role of helicobacter pylori in the pathogenesis of ICSCR so perhaps treatment of h pylori have positive effect on the remission of ICSCR.

Detailed Description

we will choose 50 cases of patients with ICSCR who are infected with h.pylori.25 cases will receive anti h.pylori regiment and 25 cases as controls will receive no medication.then we will compare the time of submacular fluid resorption and macular thickness and visual acuity among these two groups.

Study Timeline

• Study Start: 2008-03
• Primary Completion: 2008-10
• Status Verified: 2009-01
• Study Completion: 2009-01
• Study First Submitted: 2009-01-01
• Study First Submitted QC: 2009-01-05
• Last Update Submitted: 2009-01-05
• Study First Posted: 2009-01-06
• Last Update Posted: 2009-01-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• the persons who are infected with helicobacter pylori and have ICSCR

Exclusion Criteria

• history of previous eye surgery ,to have indication of laser therapy,corticosteroid therapy,pregnancy,

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	omeprazole, Amoxicillin, metronidazole	Oral Amoxicillin Capsule Metronidazole Tablet Omeprazole Capsule

Primary Outcome Measures

Name	Time	Method
Subretinal fluid level

Secondary Outcome Measures

Name	Time	Method
time of sub macular fluid absorption

Trial Locations

Locations (1)

Alireza JavadzadehTabriz; 🇮🇷 Tabriz, Iran, Islamic Republic of