Beetroot Juice - Effects on Performance in Chronic Obstructive Pulmonary Disease Patients

Not Applicable

Completed

• Conditions: Chronic Obstructive Pulmonary Disease Moderate
• Interventions: Dietary Supplement: Dietary beetroot juice

• Registration Number: NCT03020862
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) after supplementing with higher doses of dietary NO3-, compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

Detailed Description

The purpose is to evaluate exercise performance in patients with Chronic Obstructive Pulmonary Disease (COPD) using the 6-minute walk test (6MWT) after supplementing with higher doses of dietary NO3- compared to previous studies, as beetroot juice for seven days. The secondary purpose is to evaluate oxygen consumption of submaximal cycling, amendments in blood pressure, and physical activity level.

Study Timeline

• Study Start: 2013-12
• Primary Completion: 2014-04
• Status Verified: 2014-06
• Study Completion: 2015-08
• Study First Submitted: 2017-01-11
• Study First Submitted QC: 2017-01-12
• Study First Posted: 2017-01-13
• Last Update Submitted: 2017-01-13
• Last Update Posted: 2017-01-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Moderate-severe Chronics Obstructive Pulmonary Disease (COPD) (FEV1 <80% of predicted).

Exclusion Criteria

• Smoking,
• failure to complete physical testing,
• on-going participation in rehabilitation programs,
• pacemaker or use of nicotine products,
• oxygen mask,
• beta blockers,
• antibacterial mouthwash,
• chewing gum or stomach-neutralizing medicine during the intervention.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo ---> Dietary beetroot	Dietary beetroot juice	Placebo was administrated in the first period of the cross-over trial, while the intervention beverage Dietary Beetroot juice was administrated in the second period of the trial. The placebo: was an NO3- negligble drink from James White Drinks England (Beet-it), which was otherwise similar to the dietary beetroot juice in nutrient composition, smell and appearance. Dose: 2x70 mL consumed twice a day for six days. Intervention beverage, Dietary beetroot juice:Consumed as beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days.
Dietary beetroot juice --> Placebo	Dietary beetroot juice	The intervention beverage Dietary beetroot juice was administrated in the first period of the cross-over trial, while placebo was administrated in the second period of the trail Intervention beverage, Dietary beetroot juice:Consumed as beetroot juice from James White Drinks England (Beet-it) and contained 300 mg dietary nitrate. Dose: 2x70 mL consumed twice a day for six days. The placebo: was an NO3- negligble drink from James White Drinks England (Beet-it), which was otherwise similar to the dietary beetroot juice in nutrient composition, smell and appearance. Dose: 2x70 mL consumed twice a day for six days.

Primary Outcome Measures

Name	Time	Method
Physical performance on 6-min walk test (6MWT)	6 minutes

Secondary Outcome Measures

Name	Time	Method
Physical activity level	Six days	Measured all intervention days except on the day of testing
Oxygen consumption during submaximal cycling	Two trials of 6 minutes duration (10 min break between trials)
Plasma Nitrite concentration	Baseline, 150 and 210 minutes after consumption of beverages
Blood Pressure	At baseline and 150 minutes after consumption of beverages

Trial Locations

Locations (1)

Sport Science, Department of Public Health, Aarhus University; 🇩🇰 Aarhus, Denmark