KCT0000053
Recruiting
未知
Efficacy and safety of Escitalopram in the treatment of depressive patients with acute coronary artery syndrome: A double-blind placebo-controlled trial
ConditionsMental and behavioral disorders
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Mental and behavioral disorders
- Sponsor
- Chonnam National University Hospital
- Enrollment
- 300
- Status
- Recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\)Aged 18\~85
- •2\)Diagnosed as acute CAS (unstable angina or acute myocardial infarction) and being conducted coronary angiography
- •3\)Beck Depression Inventory \> 10 and major or minor depressive disorder by the DSM\-IV criteria
- •4\)With ability to complete various questionnaires
- •5\)Can understand the objective of the study and sign informed consent
Exclusion Criteria
- •1\)Occurrence of acute CAS while the patient was hospitalized for another reason, except for CAS
- •2\)Current CAS developed less than 3 months after coronary artery bypass graft procedure
- •3\)Uncontrolled hypertension (systolic BP \> 180mmHg or diastolic BP \> 100mmHg)
- •4\)Resting heart rate \< 40/min
- •5\)Severe physical illnesses threatening life or interfering with the recovery from CAS
- •6\)Persistent clinically significant laboratory abnormalities
- •7\)Concomitant use of class I antiarrhythmic medications; reserpine, guanethidine, clonidine, or methyldopa; anticonvulsants or neuroleptics
- •8\)History of neuropsychiatric illnesses such as dementia, Parkinson's disease, brain tumor, psychoses, alcoholism, and other substance dependence
- •9\)Pregnancy
Outcomes
Primary Outcomes
Not specified
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