Comparative Effects of a2 Skim Milk on Mild Cognitive Impairment in Older Adults
- Conditions
- AdultsMild Cognitive Impairment
- Registration Number
- NCT05741047
- Lead Sponsor
- a2 Milk Company Ltd.
- Brief Summary
The aim of the study is to compare the effects of powdered skim milk containing A2 β-casein only versus conventional powdered skim milk containing A1 and A2 β-casein milk on cognition, inflammation, and dietary intake in adults aged 65-75 years.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 96
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Changes of Subtle Cognitive Impairment Test (SCIT) at Visit 2 and Visit 4 compared to baseline Visit 2 (14 days after baseline); Visit 4 (90 days after baseline); baseline (14 days after enrolment) Record responding time and speed on the SCIT test
Changes of serum glutathione (GSH) at Visit 2 and Visit 4 compared to baseline Visit 2 (14 days after baseline); Visit 4 (90 days after baseline); baseline (14 days after enrolment) Record serum glutathione (GSH) (µmol/L) as an anti-oxidation marker
- Secondary Outcome Measures
Name Time Method Changes of C-reactive protein at Visit 2 and 4 compared to baseline Visit 2 (14 days after baseline); Visit 4 (90 days after baseline); baseline (14 days after enrolment) Record C-reactive protein (mg/L) as a blood marker of inflammation
Changes of short-chain fatty acids at Visit 2, 3, and 4 compared to baseline Visit 2 (14 days after baseline); Visit 3 (28 days after baseline); Visit 4 (90 days after baseline); baseline (14 days after enrolment) Record short-chain fatty acids (mg/g) as a faecal marker of inflammation
Changes of quality of life at Visit 4 compared to baseline Visit 4 (90 days after baseline); baseline (14 days after enrolment) Record Healthy Brain Ageing - Functional Assessment Questionnaire via patient self-report as a quality of life measure
Related Research Topics
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Trial Locations
- Locations (2)
General Hospital of Tianjin Medical University
🇨🇳Tianjin, China
The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
🇨🇳Tianjin, China
General Hospital of Tianjin Medical University🇨🇳Tianjin, China