Apathy in Late Life Depression: New Biomarkers Using Actimetry and Magnetic Resonance Imaging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 102
- 试验地点
- 11
- 主要终点
- Actimetry
研究概览
简要总结
Old age (> 60 years) is at high risk to develop major depression disorders (MDD). MDD doubles the risk for subsequent cognitive disorders and dementia. Apathy (i.e. the lack of motivation) is a core problem in depression in older age and is frequently associated with cognitive decline in people who have mild cognitive disorders. The investigator propose here to combine actimetry (the measurement of motor activity using a simple device worn at the wrist) and brain imaging to show that it's possible to measure apathy using actimetry in a population of elders with MDD. Having shown that apathy can reliably be measured with actimetry and that it is associated with brain abnormalities, the investigator will be able to test whether actimetry can predict cognitive decline in elders with MDD and can be routinely used in a day-to-day medical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •60 years and above
- •Major depressive disorder (either late-onset or early onset)
- •Ambulatory settings
- •Both uni and bipolar depression will be considered Healthy controls
- •60 years and above
- •No psychiatric disorders, including no major depressive disorder
- •No non-inclusion criteria
排除标准
- •Patients and healthy controls
- •Major cognitive disorders (< 125 on the Mattis dementia rating scale and a major cognitive disorders diagnostic according to the DSM5 (Diagnostic and Statistical Manual of Mental Disorders) criteria).
- •Other neurological conditions (stroke, Parkinson's disease and seizures), severe and inflammatory disorders (ex: severe arthroses which limits movements, spondylarthritis)
- •Severe sarcopenia: speed walk < 1 meter/second
- •Extrapyramidal syndrome
- •High suicidal risk
- •Anti-psychotic prescription
- •Participant who are unable to provide clear consent, under legal protection
- •MRI contra-indication
结局指标
主要结局
Actimetry
时间窗: 3 days
Measure of actimetry: immobility, transfer, walking, movement given by the accelerometer
次要结局
- cortical thickness(at Day 3 (+/- 2 days))
- diffusion tensor imaging,(at Day 3 (+/- 2 days))
- pulsatility.(at Day 3 (+/- 2 days))
- grey matter density(at Day 3 (+/- 2 days))
- Rest functional connectivity analysis(at Day 3 (+/- 2 days))