Effect of arginine-rich dietary protein on postprandial metabolism, inflammation and endothelial function - Pea Protein and Postprandial Response (PEAstudy)

Wageningen Universiteit0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•* central obesity: waist circumference >=94 cm
•plus any one of the following four factors:
•* raised triglyceride level: >=1.7 mmol/L;
•* reduced high-density lipoprotein (HDL) cholesterol: <1.03 mmol/L
•* raised blood pressure: systolic blood pressure >=130 mmHg or diastolic BP >=85 mmHg or use of blood pressure lowering medication
•* raised fasting plasma glucose >= 5.6 mmol/L
•Additional inclusion criteria:
•* age 45-65 years
•* body weight should be stable for at least 6 months
•* stable exercise habits during the last 6 months, and not participating in any vigorous exercise program

•* (undiagnosed) diabetes - but not impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) as evaluated by an oral glucose tolerance test at screening (plasma glucose: fasting > 7.0 and/or 2-hours > 11.1 mmol/L)
•* High triglyceride levels (> 5 mmol/L) or high blood pressure (> 160/95 mmHg) at screening
•* Low haemoglobin level at screening (< 7.5 mmol/L)
•* active hearth disease, i.e. history of myocardial infarction or angina pectoris
•* following, or have recently followed a (weight-loss) diet
•* drug uses knowing to interfere with the objectives of the study
•- oral corticosteroids, lipid-lowering drugs (statins)
•- ACE-inhibitors
•* Allergic to cow milk / dairy products or gluten
•* vegetarians
•* Received inoculations within 2 months of starting or planned to during the study
•* Donated or intended to donate blood 2 months before till two months after the study
•* abuse of drugs and/or alcohol
•* tobacco smoker
•* participation in another biomedical study within 1 month before the first screening visit
•* Not wanting to be informed about chance-findings during screening

发起方