Effects of the Square-Stepping Exercise on Corticomotor Excitability, Balance and Cognition in Individuals with Parkinson’s Disease

Not Applicable

Recruiting

• Conditions: Parkinson' s Disease; Parkinson’s disease; Transcranial magnetic stimulation; Square- stepping exercise; Corticomotor excitability; Balance; Cognition

• Registration Number: TCTR20180111003
• Lead Sponsor: ational Yang Ming University Department of Physical Therapy and Assistive

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-11
• Study Completion: 2019-02-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

diagnosed idiopathic PD according to the United Kingdom Brain Bank Criteria with Hoehn and Yahr stages 1 †3,aged at least 50 years of old, stable on anti-PD medications, and could walk 10m with or without any walking assist

Exclusion Criteria

-musculoskeletal or cardiopulmonary disorders
-undergone neurosurgery
-neurologic conditions other than PD
-showed cognitive deficits on the Mini-Mental State Examination (<24)
-joined another exercise program in the previous 3 months
-met the criteria for exclusion for the use of TMS (i.e. metal implants, cardiac pacemaker, history of epilepsy, previous brain injury, actively taking antidepressant drugs)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cortical excitability measured before the training, after the training and one-month follow-up measured by transcranial magnetic stimulation(TMS) using a double-cone coil

Secondary Outcome Measures

Name	Time	Method
Balance measured before the training, after the training and one-month follow-up assessed by using the Mini-Balance Evaluation Systems Test (Mini-BESTest),Cognition measured before the training, after the training and one-month follow-up measured by the Montreal Cognitive Assessment (MoCA),Cognition measured before the training, after the training and one-month follow-up measured by the Chinese version of Trail Making Test (TMT) ,Cognition measured before the training, after the training and one-month follow-up measured by the Digit Span Task (DST),Quality of life measured before the training, after the training and one-month follow-up measured by the Chinese version of the Parkinson's Disease Questionnaire (PDQ-39)