Reactive Oxygen Species (ROS) Scavenger in Adult Hemorrhagic Stroke Patients: The Effect of Perihematomal Edema Reduction and Its Subsequent Clinical Outcome

Asan Medical Center0 个研究点目标入组 110 人开始时间: 待定最近更新: 2021年1月6日

适应症

试验速览

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•1.Age =18 years and = 80 years
•2.Acute ICH due to hypertensive, cerebral amyloid angiopathy (CAA), arterio-venous malformation (AVM), cavernous malformation (CM) or venous thrombosis
•3.Brain tumor bleeding
•4.Cerebral infarct
•5.Expected ICU stay > 48 hours

•1) Trauma related brain hemorrhage
•2) ICH secondary to hematologic malignancy (acute myeloid leukemia, acute lymphocytic leukemia)
•3) ICH due to disease like moyamoya, aneurysmal SAH or hemorrhagic cyst rupture like arachnoid cyst
•4) ICH due to thrombocytopenia (< 50 000 x10³/uL) or coagulopathy (> 2 INR)
•5) Patient taking antiplatelets (aspirin, clopidogrel or cilostazole) or anticoagulation (heparin or low-molecular weight heparin [LMWH], vitamin K antagonist (warfarin) or direct oral anticoagulants [DOAC])
•6) History of cerebrovascular, tumor or any other disease that makes difficult to evaluate the extent of hemorrhage or edema from the current CT
•7) Brain death or imminent death (not expected to be in ICU for more than 48 hours)
•8) Pregnant patient
•9) Liver cirrhosis – Child’s class C liver disease
•10) Seizure disorder requiring anticonvulsant medication
•11) Post - cardiac arrest with suspected significant anoxic brain injury
•12) DNR (do not resuscitate) ordered patients

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