Is it Really Possible to Diagnose Gastric Cancer with Volatile Organic Compounds Analysis from Exhaled Breath?
- Conditions
- Neoplasms
- Registration Number
- KCT0004356
- Lead Sponsor
- The Catholic University of Korea, Seoul St. Mary's Hospital
- Brief Summary
ine VOCs differed significantly between the control and cancer patient groups. When participants were divided into control, early gastric cancer (EGC), and advanced gastric cancer (AGC) groups, seven VOCs remained significantly different. Of these, four (propanal, aceticamide, isoprene and 1,3 propanediol) showed gradual increases as cancer advanced, from normal control to EGC to AGC. In receiver operating characteristic curves for these four VOCs, the area under the curve for gastric cancer prediction was highest (0.842) when more than two VOCs were present.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 48
case : gastric cancer patient who was diagnosed through endoscopic biopsy in Seoul St. Mary's hopital
patients who are able to undergo curative gastrectomy
patients who assigned informed consent
control : participants who undergo gastroduodenoscopy in Seoul St. mary's hospital, without gastric cancer lesion
participants who assigned informed consent
participants who have any other malignancies
participants who don't agreed to sign informed consent
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method to identify the relationship between gastric cancer and specific VOCs quantified by mass spectrometry.
- Secondary Outcome Measures
Name Time Method cutoff value for each VOCs to diagnose gastric cancer