Study Comparing Intravenous (IV)/Subcutaneous (SC) Risankizumab to IV/SC Ustekinumab to Assess Change in Crohn's Disease Activity Index (CDAI) in Adult Participants With Moderate to Severe Crohn's Disease (CD)
- Conditions
- Crohn's Disease (CD)
- Interventions
- Registration Number
- NCT04524611
- Lead Sponsor
- AbbVie
- Brief Summary
Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. This study will evaluate how well risankizumab works compared to ustekinumab. This study will assess change in Crohn's Disease Activity Index (CDAI).
Risankizumab is an investigational drug being developed for the treatment of Crohn's Disease (CD). Ustekinumab is an approved drug for the treatment of moderate and severe CD. Participants are randomly assigned to one of the three treatment groups. Each group receives a different treatment. There is a 1 in 2 chance that participants will be assigned to ustekinumab. Around 508 adult participants with moderate to severe CD will be enrolled in approximately 307 sites worldwide.
In Part 1, participants assigned to risankizumab will receive intravenous (IV) doses of risankizumab at Week 0, 4,8 and subcutaneous (SC) doses every 8 weeks thereafter through Week 48. Participants assigned to ustekinumab will receive intravenous (IV) dose of ustekinumab at Week 0 and subcutaneous (SC) doses every 8 weeks thereafter through Week 48. In Part 2, participants who received risankizumab in Part 1 and completed the Week 48 visit will continue to receive SC risankizumab for up to an additional 220 weeks.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 527
- Confirmed diagnosis of Crohn's disease (CD) for at least 3 months prior to Baseline.
- Crohn's disease activity index (CDAI) score 220 - 450 at Baseline.
- Confirmed diagnosis of moderate to severe Crohn's Disease as assessed by stool frequency (SF), abdominal pain (AP) score, and Simple Endoscopic score for CD (SES-CD).
- Demonstrated intolerance or inadequate response to one or more anti-tumor necrosis factor (TNF) therapies.
- Current diagnosis of ulcerative colitis or indeterminate colitis.
- Receipt of CD approved biologic agents prior to Baseline (as detailed in protocol), or any investigational biologic or other agent or procedure prior to Baseline (as detailed in protocol).
- Prior exposure to p19 and/or p40 inhibitors (e.g., risankizumab and ustekinumab).
- Currently know complications of CD (strictures, short bowel, etc).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Ustekinumab Ustekinumab Participants will receive weight-based intravenous ustekinumab at Week 0 followed by subcutaneous ustekinumab every 8 weeks through Week 48. Risankizumab Dose A Followed by Dose B Risankizumab Participants will receive intravenous risankizumab dose A at Week 0, 4 ,8 followed by subcutaneous (SC) risankizumab dose B every 8 weeks through Week 48. Participants who complete the Week 48 visit will continue SC risankizumab for up to an additional 220 weeks.
- Primary Outcome Measures
Name Time Method Percentage of Participants Achieving Clinical Remission at Week 24 Week 24 Clinical remission is defined as Crohn's disease activity index (CDAI)\<150.
Percentage of Participants Achieving Endoscopic Remission Week 48 Endoscopic remission is defined as Simple Endoscopic Score for Crohn's Disease (SES-CD) \<= 4 and at least a 2-point reduction versus Baseline and no sub score greater than 1 in any individual variable, as scored by a central reviewer.
Number of Participants Reporting Adverse Events Up to 220 Weeks An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment. The investigator assesses the relationship of each event to the use of study. A serious adverse event (SAE) is an event that results in death, is life-threatening, requires or prolongs hospitalization, results in a congenital anomaly, persistent or significant disability/incapacity or is an important medical event that, based on medical judgment, may jeopardize the participant and may require medical or surgical intervention to prevent any of the outcomes listed above. Treatment-emergent adverse events/treatment-emergent serious adverse events (TEAEs/TESAEs) are defined as any event that began or worsened in severity on or after the first dose of study drug.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving Endoscopic Response at Week 48 Week 48 Endoscopic response is defined as decrease in Simple Endoscopic Score for Crohn's Disease (SES-CD) \> 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).
Percentage of Participants Achieving Clinical Remission at Week 48 Week 48 Clinical remission is defined as Crohn's disease activity index (CDAI)\<150.
Percentage of Participants Achieving Steroid-Free Clinical Remission Week 48 Steroid-free clinical remission is defined as participants with clinical remission and not receiving steroids at Week 48.
Percentage of Participants Achieving Endoscopic Response at Week 24 Week 24 Endoscopic response is defined as decrease in Simple Endoscopic Score for Crohn's Disease (SES-CD) \> 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).
Percentage of Participants Achieving Steroid-Free Endoscopic Remission Week 48 Steroid-free endoscopic remission is defined as participants with endoscopic remission and not receiving steroids at Week 48.
Trial Locations
- Locations (300)
Hospital Universitario Virgen Macarena /ID# 223315
๐ช๐ธSevilla, Spain
Hospital Clinico Universitario de Valencia /ID# 223321
๐ช๐ธValencia, Spain
Axler, Toronto, ON. Canada /ID# 223740
๐จ๐ฆToronto, Ontario, Canada
The University of Chicago DCAM /ID# 223520
๐บ๐ธChicago, Illinois, United States
Duplicate_Baylor College of Medicine - Baylor Medical Center /ID# 223488
๐บ๐ธHouston, Texas, United States
University of Miami /ID# 223496
๐บ๐ธMiami, Florida, United States
AZ Maria Middelares /ID# 223908
๐ง๐ชGent, Belgium
Acibadem City Clinic Tokuda University Hospital EAD /ID# 223757
๐ง๐ฌSofia, Bulgaria
Hospital Tsaritsa Yoanna /ID# 223822
๐ง๐ฌSofiya, Sofia, Bulgaria
2nd Mhat /ID# 223425
๐ง๐ฌSofia, Bulgaria
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 223342
๐ฌ๐ทAthens, Attiki, Greece
Covenant Health /ID# 223753
๐จ๐ฆEdmonton, Alberta, Canada
General Hospital of Athens Ippokratio /ID# 223344
๐ฌ๐ทAthens, Attiki, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 223338
๐ฌ๐ทAthens, Greece
General Hospital of Thessaloniki Hippokrateio /ID# 223887
๐ฌ๐ทThessaloniki, Greece
The Edith Wolfson Medical Center /ID# 227652
๐ฎ๐ฑAshkelon, HaDarom, Israel
Sana Monitoring /Id# 223682
๐ท๐ดBucharest, Romania
Oxford University Hospitals NHS Foundation Trust /ID# 223645
๐ฌ๐งOxford, Oxfordshire, United Kingdom
Gazi Universitesi Tip Fakultes /ID# 223386
๐น๐ทYenimahalle, Ankara, Turkey
Lviv Regional Clinical Hospital /ID# 223661
๐บ๐ฆLviv, Ukraine
Medical Center of LLC DIASERVIS /ID# 224249
๐บ๐ฆZaporizhzhia, Ukraine
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 223327
๐ฎ๐นNegrar, Verona, Italy
Duplicate_University of California, San Francisco /ID# 223621
๐บ๐ธSan Francisco, California, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 223510
๐บ๐ธSan Antonio, Texas, United States
Southern Star Research Institute, LLC /ID# 223598
๐บ๐ธSan Antonio, Texas, United States
Mayo Clinic - Rochester /ID# 223506
๐บ๐ธRochester, Minnesota, United States
TLC Clinical Research Inc /ID# 223467
๐บ๐ธLos Angeles, California, United States
Gastroenterology Group Naples /ID# 223516
๐บ๐ธNaples, Florida, United States
Duplicate_Western Connecticut Medical Group /ID# 223478
๐บ๐ธDanbury, Connecticut, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 223525
๐บ๐ธMacon, Georgia, United States
Southern California Res. Ctr. /ID# 223484
๐บ๐ธCoronado, California, United States
United Medical Doctors /ID# 223486
๐บ๐ธLos Alamitos, California, United States
Massachusetts General Hospital /Id# 224335
๐บ๐ธBoston, Massachusetts, United States
Beth Israel Deaconess Medical Center /ID# 228094
๐บ๐ธBoston, Massachusetts, United States
Penn State Milton S. Hershey Medical Center /ID# 224216
๐บ๐ธHershey, Pennsylvania, United States
Atlanta Gastro Assoc /ID# 223537
๐บ๐ธAtlanta, Georgia, United States
NY Scientific /ID# 223479
๐บ๐ธBrooklyn, New York, United States
AA Medical Research Center - Flint /ID# 224384
๐บ๐ธFlint, Michigan, United States
Texas Digestive Disease Consultants - Southlake /ID# 224264
๐บ๐ธSouthlake, Texas, United States
Univ New Mexico /ID# 223515
๐บ๐ธAlbuquerque, New Mexico, United States
Plains Clinical Research Center, LLC /ID# 223522
๐บ๐ธFargo, North Dakota, United States
Duplicate_MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 223499
๐บ๐ธChevy Chase, Maryland, United States
Intercity Advanced Gastroentertology Center /ID# 224313
๐บ๐ธFresh Meadows, New York, United States
Digestive Disease Associates, LTD /ID# 223462
๐บ๐ธWyomissing, Pennsylvania, United States
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 223465
๐บ๐ธWyoming, Michigan, United States
University of Cincinnati Medical Center /ID# 224614
๐บ๐ธCincinnati, Ohio, United States
Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 223512
๐บ๐ธDallas, Texas, United States
Vilo Research Group Inc /ID# 223513
๐บ๐ธHouston, Texas, United States
Digestive Disease Specialists /ID# 223528
๐บ๐ธOklahoma City, Oklahoma, United States
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 223233
๐ง๐ทRibeirรฃo Preto, Sao Paulo, Brazil
Guthrie Medical Group, PC /ID# 223910
๐บ๐ธSayre, Pennsylvania, United States
Mount Sinai Hospital /ID# 223752
๐จ๐ฆToronto, Ontario, Canada
Wollongong Hospital /ID# 224688
๐ฆ๐บWollongong, New South Wales, Australia
Scott Shulman Medicine Professional Corporation /ID# 223754
๐จ๐ฆNorth Bay, Ontario, Canada
CHU de Liege /ID# 223904
๐ง๐ชLiege, Belgium
Duplicate_DHAT Research Institute /ID# 223521
๐บ๐ธGarland, Texas, United States
Virginia Mason Hospital & Medical Center /ID# 224253
๐บ๐ธSeattle, Washington, United States
Harborview Medical Center /ID# 224464
๐บ๐ธSeattle, Washington, United States
Tyler Research Institute, LLC /ID# 223469
๐บ๐ธTyler, Texas, United States
Kaiser Clinica e Hospital Dia /ID# 223232
๐ง๐ทSao Jose Do Rio Preto, Sao Paulo, Brazil
Faculdade de Medicina do ABC /ID# 223231
๐ง๐ทSanto Andrรฉ, La Spezia, Brazil
Duplicate_Sanatorio 9 de Julio /ID# 226086
๐ฆ๐ทSan Miguel de Tucuman, Tucuman, Argentina
Duplicate_CHU UCL Namur - site Godinne /ID# 223905
๐ง๐ชGodinne, Namur, Belgium
Percuro Clinical Research, Ltd /ID# 223747
๐จ๐ฆVictoria, British Columbia, Canada
Anhui Provincial Hospital /ID# 224832
๐จ๐ณHefei, Anhui, China
Chongqing General Hospital /ID# 232305
๐จ๐ณChongqing, Chongqing, China
Zhongshan Hospital Xiamen University /ID# 224663
๐จ๐ณXiamen, Fujian, China
Hospital Guillermo Grant Benavente de Concepciรณn /ID# 223668
๐จ๐ฑConcepciรณn, Chile
Montreal General Hospital- McGill University Health Center /ID# 223743
๐จ๐ฆMontreal, Canada
CHUS - Hopital Fleurimont /ID# 224819
๐จ๐ฆSherbrooke, Quebec, Canada
Peking University Third Hospital /ID# 224479
๐จ๐ณBeijing, Beijing, China
Centre Medico Chirurgical Ambroise Pare Hartmann /ID# 249859
๐ซ๐ทNeuilly Sur Seine, Ile-de-France, France
Zhujiang Hospital of Southern Medical University /ID# 224524
๐จ๐ณGuangzhou, Guangdong, China
Eugastro /ID# 223401
๐ฉ๐ชLeipzig, Sachsen, Germany
Medizinisches Versorgungszentrum Portal 10 /ID# 224552
๐ฉ๐ชMuenster, Germany
Medizinische Hochschule Hannover /ID# 223402
๐ฉ๐ชHannover, Germany
Axon Clinical, s.r.o. /ID# 223260
๐จ๐ฟPraha, Czechia
Universitatsklinikum Mannheim /ID# 223410
๐ฉ๐ชMannheim, Baden-Wuerttemberg, Germany
CHU Reims - Hรดpital Robert Debre /ID# 224530
๐ซ๐ทReims CEDEX, Marne, France
The Sixth Affiliated Hosp Sun /ID# 224416
๐จ๐ณGuangzhou, Guangdong, China
Ospedale San Raffaele IRCCS /ID# 241167
๐ฎ๐นMilan, Milano, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 223332
๐ฎ๐นRome, Roma, Italy
CHU Montpellier - Hopital Saint Eloi /ID# 223860
๐ซ๐ทMontpellier Cedex 5, Herault, France
Hopital Beaujon /ID# 223863
๐ซ๐ทClichy, Ile-de-France, France
Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 223403
๐ฉ๐ชDresden, Germany
Renmin Hospital of Wuhan University /ID# 224525
๐จ๐ณWuhan, Hubei, China
Universitaetsklinikum Frankfurt /ID# 223396
๐ฉ๐ชFrankfurt am Main, Hessen, Germany
Nemocnice Pardubickeho kraje, a.s. /ID# 223256
๐จ๐ฟPardubice, Czechia
The Second Xiangya Hospital of Central South University /ID# 224684
๐จ๐ณChangsha, China
Nanjing Drum Tower Hospital /ID# 224746
๐จ๐ณNanjing, Jiangsu, China
Duplicate_CHU Grenoble - Hopital Michallon /ID# 224091
๐ซ๐ทLa Tronche, Isere, France
Praxiszentrum fuer Gastroenterologie /ID# 223409
๐ฉ๐ชGrevenbroich, Nordrhein-Westfalen, Germany
Klinikum Lueneburg /ID# 223408
๐ฉ๐ชLueneburg, Germany
Duplicate_Agaplesion Markus Krankenhaus /ID# 223673
๐ฉ๐ชFrankfurt am Main, Hessen, Germany
Zentrum fรผr Gastroenterologie Saar MVZ GmbH /ID# 223482
๐ฉ๐ชSaarbrรผcken, Saarland, Germany
Hopital Universitaire Purpan Hopital Rangueil /ID# 224732
๐ซ๐ทToulouse, France
Universitaetsklinikum Erlangen /ID# 223404
๐ฉ๐ชErlangen, Bayern, Germany
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 224545
๐จ๐ณWuhan, Hubei, China
CHRU Nancy - Hopitaux de Brabois /ID# 223767
๐ซ๐ทVandoeuvre-les-Nancy, Meurthe-et-Moselle, France
Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 224420
๐จ๐ณShanghai, Shanghai, China
West China Hospital, Sichuan University /ID# 224786
๐จ๐ณChengdu, Sichuan, China
CHU Clermont-Ferrand /ID# 224529
๐ซ๐ทClermont, Auvergne-Rhone-Alpes, France
APHM - Hopital Nord /ID# 223869
๐ซ๐ทMarseille, Bouches-du-Rhone, France
Polyclinique Grand Sud /ID# 224092
๐ซ๐ทNimes Cedex, France
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 223395
๐ฉ๐ชKiel, Schleswig-Holstein, Germany
Centre Hospitalier Universitaire de Saint รtienne - Hรดpital Nord /ID# 223768
๐ซ๐ทSt-Priest-en-Jarez, France
Universitatsklinik Regensburg /ID# 223407
๐ฉ๐ชRatisbon, Bayern, Germany
Universitaetsklinikum Freiburg /ID# 223406
๐ฉ๐ชFreiburg, Baden-Wuerttemberg, Germany
University General Hospital of Heraklion PA.G.N.I /ID# 223336
๐ฌ๐ทHeraklion, Kriti, Greece
Krankenhaus Waldfriede /ID# 223397
๐ฉ๐ชBerlin-Zehlendorf, Germany
Duplicate_Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 223405
๐ฉ๐ชBerlin, Germany
Ospedale Policlinico San Martino /ID# 223329
๐ฎ๐นGenoa, Genova, Italy
Shaare Zedek Medical Center /ID# 223549
๐ฎ๐ฑJerusalem, Yerushalayim, Israel
ASST Rhodense/Presidio Ospedaliero di Rho /ID# 223335
๐ฎ๐นRho, Milano, Italy
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 223324
๐ฎ๐นMilan, Italy
Duplicate_Kangbuk Samsung Hospital /ID# 223452
๐ฐ๐ทSeoul, Seoul Teugbyeolsi, Korea, Republic of
Medical Care & Research SA de CV /ID# 223974
๐ฒ๐ฝMรฉrida, Yucatan, Mexico
Mersin University Medical /ID# 223385
๐น๐ทMersin, Turkey
Cabinet Particular Policlinic Algomed /ID# 223578
๐ท๐ดTimiศoara, Romania
Barts Health NHS Trust /ID# 223651
๐ฌ๐งLondon, London, City Of, United Kingdom
Guys and St Thomas NHS Foundation Trust /ID# 223647
๐ฌ๐งLondon, London, City Of, United Kingdom
Universitรคtsspital Basel /ID# 223711
๐จ๐ญBasel Town, Basel-Stadt, Switzerland
Hospital Universitario Virgen del Rocio /ID# 223476
๐ช๐ธSevilla, Spain
Danderyds sjukhus AB /ID# 223363
๐ธ๐ชStockholm, Sweden
Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 223387
๐น๐ทIstanbul, Turkey
National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 224222
๐ท๐บMoscow, Russian Federation
Hospital General Universitario de Alicante Doctor Balmis /ID# 223552
๐ช๐ธAlicante, Spain
Lenasia Clinical Trial Centre /ID# 224306
๐ฟ๐ฆJohannesburg, Gauteng, South Africa
Ankara Univ Medical Faculty /ID# 223388
๐น๐ทAnkara, Turkey
Calderdale and Huddersfield NHS Foundation Trust /ID# 223654
๐ฌ๐งHuddersfield, United Kingdom
King's College Hospital NHS Foundation Trust /ID# 223649
๐ฌ๐งLondon, United Kingdom
Belfast Health and Social Care Trust /ID# 224023
๐ฌ๐งBelfast, United Kingdom
NHS Lothian /ID# 223646
๐ฌ๐งEdinburgh, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 223655
๐ฌ๐งNewcastle upon Tyne, United Kingdom
Northern Care Alliance NHS Group /ID# 223650
๐ฌ๐งSalford, United Kingdom
NHS Forth Valley /ID# 224657
๐ฌ๐งStirling, United Kingdom
St George's University Hospitals NHS Foundation Trust /ID# 223656
๐ฌ๐งTooting, United Kingdom
Duplicate_University of South Florida /ID# 224733
๐บ๐ธTampa, Florida, United States
Hightower Clinical /ID# 223566
๐บ๐ธOklahoma City, Oklahoma, United States
Nemocnice Horovice - NH Hospital a.s /ID# 223276
๐จ๐ฟPraha, Czechia
Griffith University /ID# 223641
๐ฆ๐บSouthport, Queensland, Australia
Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 224048
๐บ๐ธBurnt Hills, New York, United States
Columbia Univ Medical Center /ID# 224215
๐บ๐ธNew York, New York, United States
Lenox Hill Hospital /ID# 223534
๐บ๐ธNew York, New York, United States
Nature Coast Clinical Research - Inverness /ID# 223600
๐บ๐ธInverness, Florida, United States
Advanced Research Institute, Inc /ID# 223470
๐บ๐ธNew Port Richey, Florida, United States
Cleveland Clinic Main Campus /ID# 223691
๐บ๐ธCleveland, Ohio, United States
Otto-von-Guericke-Universitaet /ID# 223413
๐ฉ๐ชMagdeburg, Germany
Omega Research Maitland, LLC /ID# 223463
๐บ๐ธDeBary, Florida, United States
Southwest Gastroenterology /ID# 223509
๐บ๐ธOak Lawn, Illinois, United States
North Shore University Hospital /ID# 224356
๐บ๐ธNew Hyde Park, New York, United States
The Mount Sinai Hospital /ID# 223687
๐บ๐ธNew York, New York, United States
Gastroenterology Associates, P.A. of Greenville /ID# 223497
๐บ๐ธGreenville, South Carolina, United States
DSI Research, LLC /ID# 234116
๐บ๐ธSpringboro, Ohio, United States
Gastro One /ID# 223539
๐บ๐ธCordova, Tennessee, United States
Mater Misericordiae Limited /ID# 223642
๐ฆ๐บSouth Brisbane, Queensland, Australia
Hospital Italiano de Buenos Aires /ID# 224550
๐ฆ๐ทCiudad Autonoma Buenos Aires, Ciudad Autonoma De Buenos Aires, Argentina
Universitaetsklinikum St. Poelten /ID# 223437
๐ฆ๐นSankt Poelten, Niederoesterreich, Austria
Lyell McEwin Hospital /ID# 223643
๐ฆ๐บElizabeth Vale, South Australia, Australia
Universitair Ziekenhuis Leuven /ID# 223901
๐ง๐ชLeuven, Vlaams-Brabant, Belgium
Upeclin Fmb - Unesp /Id# 223234
๐ง๐ทBotucatu, Sao Paulo, Brazil
Allen Whey Khye Lim Professional Corporation /ID# 223755
๐จ๐ฆEdmonton, Alberta, Canada
London Health Sciences Center- University Hospital /ID# 223741
๐จ๐ฆLondon, Ontario, Canada
CISSS de la Monteregie /ID# 224399
๐จ๐ฆGreenfield Park, Quebec, Canada
Sociedad de Servicios Medicos Walsen Galmez /ID# 224032
๐จ๐ฑSantiago, Region Metropolitana De Santiago, Chile
Hospital Las Higueras /ID# 223669
๐จ๐ฑTalcahuano, Chile
The Second Affiliated Hospital of Zhengzhou University /ID# 224528
๐จ๐ณZhengzhou, Henan, China
Duplicate_The Third Xiangya Hospital of Central South University /ID# 224754
๐จ๐ณChangsha, Hunan, China
Tongji Hospital Tongji Medical College of HUST /ID# 224428
๐จ๐ณWuhan, Hubei, China
Changzhou No.2 People's Hospital /ID# 238965
๐จ๐ณChangzhou, Jiangsu, China
Wuxi People's Hospital /ID# 224426
๐จ๐ณWuxi, Jiangsu, China
The First Affiliated Hospital of Nanchang University /ID# 224507
๐จ๐ณNanchang, Jiangxi, China
Shengjing Hospital of China Medical University /ID# 224478
๐จ๐ณShenyang, Liaoning, China
The second affiliated hospital of Zhejiang University school of medicine /ID# 224662
๐จ๐ณHangzhou, Zhejiang, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine /ID# 224421
๐จ๐ณHangzhou, Zhejiang, China
Iscare Klinickรฉ Centrum /ID# 223279
๐จ๐ฟPrague, Praha 9, Czechia
Nemocnice Ceske Budejovice a.s. /ID# 224219
๐จ๐ฟCeske Budejovice, Czechia
Hepato-Gastroenterologie HK, s.r.o. /ID# 223277
๐จ๐ฟHradec Kralove, Czechia
CHRU Lille - Hopital Claude Huriez /ID# 223765
๐ซ๐ทLille, Nord, France
ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 223322
๐ฎ๐นMilano, Italy
Clinique Jules Verne /ID# 223870
๐ซ๐ทNantes, France
Universitaetsklinikum Ulm /ID# 223400
๐ฉ๐ชUlm, Baden-Wuerttemberg, Germany
Azienda Ospedaliera G. Brotzu /ID# 241165
๐ฎ๐นCagliari, Italy
Praxis Dr. Michael Mross /ID# 229110
๐ฉ๐ชBerlin, Germany
DRK Kliniken Berlin Westend /ID# 223412
๐ฉ๐ชBerlin, Germany
University General Hospital of Ioannina /ID# 223339
๐ฌ๐ทIoannina, Greece
The Chaim Sheba Medical Center /ID# 223557
๐ฎ๐ฑRamat Gan, Tel-Aviv, Israel
Rabin Medical Center /ID# 223558
๐ฎ๐ฑHaifa, Israel
Azienda Ospedaliera San Camillo Forlanini /ID# 223325
๐ฎ๐นRome, Roma, Italy
Azienda Ospedaliero Universitaria di Cagliari- Presidio Ospedaliero /ID# 223474
๐ฎ๐นCagliari, Italy
Policlinico Agostino Gemelli /ID# 223323
๐ฎ๐นRome, Roma, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 223330
๐ฎ๐นBologna, Italy
A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 223333
๐ฎ๐นPalermo, Italy
Duplicate_Dong-A University Hospital /ID# 223455
๐ฐ๐ท์๊ตฌ, Gyeongsangnamdo, Korea, Republic of
Duplicate_The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 223456
๐ฐ๐ท์ค๊ตฌ, Daejeon Gwang Yeogsi, Korea, Republic of
Samsung Medical Center /ID# 223453
๐ฐ๐ทSeoul, Korea, Republic of
Amsterdam UMC, locatie AMC /ID# 223228
๐ณ๐ฑAmsterdam, Noord-Holland, Netherlands
Centro de Investigacion en Artritis y Osteoporosis S.C. /ID# 227179
๐ฒ๐ฝMexicali, Baja California, Mexico
BRCR Global Mexico /ID# 223970
๐ฒ๐ฝGuadalajara, Jalisco, Mexico
Radboud Universitair Medisch Centrum /ID# 233750
๐ณ๐ฑNijmegen, Gelderland, Netherlands
Centro Medico Zambrano Hellion /ID# 224025
๐ฒ๐ฝSan Pedro Garza Garcia, Nuevo Leon, Mexico
Elisabeth Tweesteden Ziekenhuis /ID# 223229
๐ณ๐ฑTilburg, Netherlands
NZOZ Vivamed Jadwiga Miecz /ID# 223706
๐ต๐ฑWarszawa, Mazowieckie, Poland
Universitair Medisch Centrum Utrecht /ID# 223696
๐ณ๐ฑUtrecht, Netherlands
Gastromed Sp. z o.o /ID# 223705
๐ต๐ฑTorun, Kujawsko-pomorskie, Poland
Malopolskie Centrum Kliniczne /ID# 223708
๐ต๐ฑKrakow, Malopolskie, Poland
Univ Emergency Hosp Bucharest /ID# 223579
๐ท๐ดBucuresti, Romania
Duplicate_Institutul Clinic Fundeni /ID# 223914
๐ท๐ดBucharest, Bucuresti, Romania
Spitalul Clinic Colentina /ID# 223680
๐ท๐ดBucuresti, Romania
Spitalul Clinic Judetean de Urgenta Targu Mures /ID# 224017
๐ท๐ดTargu Mures, Romania
Targu Mures Emergency Clinical County Hospital /ID# 223613
๐ท๐ดTargu Mures, Romania
Duplicate_GASTRO I., s.r.o. /ID# 223303
๐ธ๐ฐPresov, Presovsky Kraj, Slovakia
City Clinical Hospital No. 31 /ID# 224223
๐ท๐บSt. Petersburg, Russian Federation
Spoke Research Inc /ID# 223803
๐ฟ๐ฆCAPE TOWN Milnerton, Western Cape, South Africa
Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 223356
๐ช๐ธFerrol, A Coruna, Spain
Hospital Clรญnico Universitario de Santiago-CHUS /ID# 226554
๐ช๐ธSantiago de Compostela, A Coruna, Spain
Fakultna nemocnica s poliklinikou Nove Zamky /ID# 224580
๐ธ๐ฐNove Zamky, Slovakia
Dr MJ Prins /ID# 224304
๐ฟ๐ฆCape Town, Western Cape, South Africa
Private Practice Dr MN Rajabally /ID# 223805
๐ฟ๐ฆCape Town, Western Cape, South Africa
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 223302
๐ธ๐ฐBanska Bystrica, Slovakia
Hospital Universitario Puerta de Hierro - Majadahonda /ID# 223319
๐ช๐ธMajadahonda, Madrid, Spain
Duplicate_Hospital Universitario de Bellvitge /ID# 225719
๐ช๐ธL'Hospitalet de Llobregat, Barcelona, Spain
Hospital General Universitario Gregorio Maranon /ID# 223317
๐ช๐ธMadrid, Spain
Hospital Universitario Germans Trias i Pujol /ID# 223436
๐ช๐ธBadalona, Barcelona, Spain
Hospital Clinico Universitario San Carlos /ID# 223367
๐ช๐ธMadrid, Spain
Hospital Universitario La Paz /ID# 223318
๐ช๐ธMadrid, Spain
Hospital Universitario de Fuenlabrada /ID# 223371
๐ช๐ธFuenlabrada, Madrid, Spain
Hospital Clinic de Barcelona /ID# 223355
๐ช๐ธBarcelona, Spain
Hospital Universitario y Politecnico La Fe /ID# 223314
๐ช๐ธValencia, Spain
GHP Stockholm Gastro Center /ID# 223420
๐ธ๐ชStockholm, Stockholms Lan, Sweden
Duplicate_Falu Lasarett /ID# 227222
๐ธ๐ชFalun, Sweden
Karolinska University Hospital Solna /ID# 223423
๐ธ๐ชSolna, Stockholms Lan, Sweden
Royal Devon & Exeter Hospital /ID# 223644
๐ฌ๐งExeter, Devon, United Kingdom
East and North Hertfordshire NHS Trust /ID# 224607
๐ฌ๐งStevenage, Hertfordshire, United Kingdom
Gastro Center of Maryland /ID# 223518
๐บ๐ธColumbia, Maryland, United States
Hoag Memorial Hosp Presbyterian /ID# 224373
๐บ๐ธIrvine, California, United States
NorthShore University HealthSystem /ID# 223538
๐บ๐ธEvanston, Illinois, United States
QEII - Health Sciences Centre /ID# 223748
๐จ๐ฆHalifax, Nova Scotia, Canada
Nola Research Works, LLC /ID# 223489
๐บ๐ธNew Orleans, Louisiana, United States
Univ NC Chapel Hill /ID# 224405
๐บ๐ธChapel Hill, North Carolina, United States
Richmond VA Medical Center /ID# 223586
๐บ๐ธRichmond, Virginia, United States
Duplicate_UC Davis Medical Center /ID# 225700
๐บ๐ธSacramento, California, United States
Yale Univ Digestive Diseases /ID# 224463
๐บ๐ธNew Haven, Connecticut, United States
Endoscopic Research, Inc. /ID# 223505
๐บ๐ธOrlando, Florida, United States
University of Louisville Hospital /ID# 223471
๐บ๐ธLouisville, Kentucky, United States
University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 223597
๐บ๐ธAnn Arbor, Michigan, United States
Atrium Health Wake Forest Baptist Medical Center /ID# 224406
๐บ๐ธWinston-Salem, North Carolina, United States
Advanced Gastroenterology, P.C /ID# 224396
๐บ๐ธChandler, Arizona, United States
Las Vegas Medical Research /ID# 223533
๐บ๐ธLas Vegas, Nevada, United States
Duplicate_Medical Research Center of CT /ID# 223540
๐บ๐ธHamden, Connecticut, United States
Consultants in Gastroenterology - Columbia NE /ID# 224263
๐บ๐ธColumbia, South Carolina, United States
Vanderbilt University Medical Center /ID# 224610
๐บ๐ธNashville, Tennessee, United States
Medical University of South Carolina /ID# 223485
๐บ๐ธCharleston, South Carolina, United States
GI Alliance /ID# 223508
๐บ๐ธBaton Rouge, Louisiana, United States
Louisiana Research Center, LLC /ID# 223503
๐บ๐ธShreveport, Louisiana, United States
University of Vermont Medical Center /ID# 224047
๐บ๐ธBurlington, Vermont, United States
CINME Centro de Investigaciones Metabolicas /ID# 223447
๐ฆ๐ทCiudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Gedyt /ID# 224698
๐ฆ๐ทCiudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Hospital Britanico de Buenos Aires /ID# 223432
๐ฆ๐ทCiudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Cemic /Id# 223670
๐ฆ๐ทCiudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 223433
๐ฆ๐ทCordoba, Argentina
Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 223440
๐ฆ๐นLinz, Oberoesterreich, Austria
Medizinische Universitaet Wien /ID# 223438
๐ฆ๐นVienna, Wien, Austria
Universite Libre de Bruxelles - Hopital Erasme /ID# 223902
๐ง๐ชAnderlecht, Bruxelles-Capitale, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 223900
๐ง๐ชWoluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
UZ Gent /ID# 223899
๐ง๐ชGent, Oost-Vlaanderen, Belgium
Vitaz /Id# 224511
๐ง๐ชSint-Niklaas, Oost-Vlaanderen, Belgium
AZ-Delta /ID# 223896
๐ง๐ชRoeselare, West-Vlaanderen, Belgium
Groupe Sante CHC - Clinique du MontLegia /ID# 223898
๐ง๐ชLiege, Belgium
ZNA - Jan Palfijn /ID# 223907
๐ง๐ชMerksem, Belgium
University of Calgary /ID# 223750
๐จ๐ฆCalgary, Alberta, Canada
UMHAT Kaspela EOOD /ID# 223415
๐ง๐ฌPlovdiv, Bulgaria
CSSS Alphonse-Desjardins, CHAU de Levis /ID# 223744
๐จ๐ฆLevis, Quebec, Canada
West Virginia University Hospitals /ID# 223501
๐บ๐ธMorgantown, West Virginia, United States
Monash Medical Centre /ID# 224599
๐ฆ๐บClayton, Victoria, Australia
CHU de Nantes, Hotel Dieu -HME /ID# 241098
๐ซ๐ทNantes, Pays-de-la-Loire, France
Chu de Nice-Hopital Larchet Ii /Id# 223763
๐ซ๐ทNice, Alpes-Maritimes, France
Duplicate_CHU Bordeaux - Hopital Haut Leveque /ID# 223764
๐ซ๐ทPessac, Gironde, France
General Hospital of Nikaia-Piraeus "Agios Panteleimon" /ID# 223340
๐ฌ๐ทNikaia, Greece
Yitzhak Shamir Medical Center /ID# 224686
๐ฎ๐ฑZerifin, HaMerkaz, Israel
Immanuel Kant Baltic Federal University /ID# 224224
๐ท๐บKaliningrad, Kaliningradskaya Oblast, Russian Federation
KM Management, spol. s.r.o. /ID# 223304
๐ธ๐ฐNitra, Nitriansky Kraj, Slovakia
Kyiv City Clinical Hospital No.18 /ID# 223700
๐บ๐ฆKyiv, Ukraine
University Hospital Southampton NHS Foundation Trust /ID# 224351
๐ฌ๐งSouthampton, Hampshire, United Kingdom
Duplicate_Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont /ID# 223774
๐ญ๐บSzeged, Csongrad, Hungary
Duplicate_Clinfan Szolgaltato Kft. /ID# 224751
๐ญ๐บSzekszard, Tolna, Hungary
Tel Aviv Sourasky Medical Center /ID# 223551
๐ฎ๐ฑTel Aviv, Tel-Aviv, Israel
Duplicate_Debreceni Egyetem Klinikai Kozpont /ID# 223773
๐ญ๐บDebrecen, Hajdu-Bihar, Hungary
Soroka University Medical Center /ID# 223556
๐ฎ๐ฑBe'er Sheva, HaDarom, Israel
Faicic S de Rl de Cv /Id# 226990
๐ฒ๐ฝVeracruz, Mexico
Inselspital, Universitaetsspital Bern /ID# 223590
๐จ๐ญBern, Switzerland
Duplicate_Nottingham University Hospitals NHS Trust /ID# 224179
๐ฌ๐งNottingham, Nottinghamshire, United Kingdom
Hospital Universitario Central de Asturias /ID# 223368
๐ช๐ธOviedo, Asturias, Spain
NHS Greater Glasgow and Clyde /ID# 223653
๐ฌ๐งGlasgow, Scotland, United Kingdom
Semmelweis Egyetem /ID# 223772
๐ญ๐บBudapest, Hungary
Duplicate_Universitatsspital Zurich /ID# 223712
๐จ๐ญZurich, Zuerich, Switzerland
Addenbrooke's Hospital /ID# 223648
๐ฌ๐งCambridge, Cambridgeshire, United Kingdom
MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 223411
๐ฉ๐ชBerlin, Germany
Fraser Clinical Trials Inc /ID# 223742
๐จ๐ฆNew Westminster, British Columbia, Canada
Clinexpert Kft /ID# 223775
๐ญ๐บBudapest, Hungary
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