Study Comparing Intravenous (IV)/Subcutaneous (SC) Risankizumab to IV/SC Ustekinumab to Assess Change in Crohn's Disease Activity Index (CDAI) in Adult Participants With Moderate to Severe Crohn's Disease (CD)
- Conditions
- Crohn's Disease (CD)
- Interventions
- Registration Number
- NCT04524611
- Lead Sponsor
- AbbVie
- Brief Summary
Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. This study will evaluate how well risankizumab works compared to ustekinumab. This study will assess change in Crohn's Disease Activity Index (CDAI).
Risankizumab is an investigational drug being developed for the treatment of Crohn's Disease (CD). Ustekinumab is an approved drug for the treatment of moderate and severe CD. Participants are randomly assigned to one of the three treatment groups. Each group receives a different treatment. There is a 1 in 2 chance that participants will be assigned to ustekinumab. Around 508 adult participants with moderate to severe CD will be enrolled in approximately 307 sites worldwide.
In Part 1, participants assigned to risankizumab will receive intravenous (IV) doses of risankizumab at Week 0, 4,8 and subcutaneous (SC) doses every 8 weeks thereafter through Week 48. Participants assigned to ustekinumab will receive intravenous (IV) dose of ustekinumab at Week 0 and subcutaneous (SC) doses every 8 weeks thereafter through Week 48. In Part 2, participants who received risankizumab in Part 1 and completed the Week 48 visit will continue to receive SC risankizumab for up to an additional 220 weeks.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 527
- Confirmed diagnosis of Crohn's disease (CD) for at least 3 months prior to Baseline.
- Crohn's disease activity index (CDAI) score 220 - 450 at Baseline.
- Confirmed diagnosis of moderate to severe Crohn's Disease as assessed by stool frequency (SF), abdominal pain (AP) score, and Simple Endoscopic score for CD (SES-CD).
- Demonstrated intolerance or inadequate response to one or more anti-tumor necrosis factor (TNF) therapies.
- Current diagnosis of ulcerative colitis or indeterminate colitis.
- Receipt of CD approved biologic agents prior to Baseline (as detailed in protocol), or any investigational biologic or other agent or procedure prior to Baseline (as detailed in protocol).
- Prior exposure to p19 and/or p40 inhibitors (e.g., risankizumab and ustekinumab).
- Currently know complications of CD (strictures, short bowel, etc).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Ustekinumab Ustekinumab Participants will receive weight-based intravenous ustekinumab at Week 0 followed by subcutaneous ustekinumab every 8 weeks through Week 48. Risankizumab Dose A Followed by Dose B Risankizumab Participants will receive intravenous risankizumab dose A at Week 0, 4 ,8 followed by subcutaneous (SC) risankizumab dose B every 8 weeks through Week 48. Participants who complete the Week 48 visit will continue SC risankizumab for up to an additional 220 weeks.
- Primary Outcome Measures
Name Time Method Percentage of Participants Achieving Clinical Remission at Week 24 Week 24 Clinical remission is defined as Crohn's disease activity index (CDAI)\<150.
Percentage of Participants Achieving Endoscopic Remission Week 48 Endoscopic remission is defined as Simple Endoscopic Score for Crohn's Disease (SES-CD) \<= 4 and at least a 2-point reduction versus Baseline and no sub score greater than 1 in any individual variable, as scored by a central reviewer.
Number of Participants Reporting Adverse Events Up to 220 Weeks An adverse event (AE) is defined as any untoward medical occurrence in a patient or clinical investigation participant administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment. The investigator assesses the relationship of each event to the use of study. A serious adverse event (SAE) is an event that results in death, is life-threatening, requires or prolongs hospitalization, results in a congenital anomaly, persistent or significant disability/incapacity or is an important medical event that, based on medical judgment, may jeopardize the participant and may require medical or surgical intervention to prevent any of the outcomes listed above. Treatment-emergent adverse events/treatment-emergent serious adverse events (TEAEs/TESAEs) are defined as any event that began or worsened in severity on or after the first dose of study drug.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving Endoscopic Response at Week 48 Week 48 Endoscopic response is defined as decrease in Simple Endoscopic Score for Crohn's Disease (SES-CD) \> 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).
Percentage of Participants Achieving Clinical Remission at Week 48 Week 48 Clinical remission is defined as Crohn's disease activity index (CDAI)\<150.
Percentage of Participants Achieving Steroid-Free Clinical Remission Week 48 Steroid-free clinical remission is defined as participants with clinical remission and not receiving steroids at Week 48.
Percentage of Participants Achieving Endoscopic Response at Week 24 Week 24 Endoscopic response is defined as decrease in Simple Endoscopic Score for Crohn's Disease (SES-CD) \> 50% from Baseline (or for participants with isolated ileal disease and a Baseline SES-CD of 4, at least a 2-point reduction from Baseline).
Percentage of Participants Achieving Steroid-Free Endoscopic Remission Week 48 Steroid-free endoscopic remission is defined as participants with endoscopic remission and not receiving steroids at Week 48.
Trial Locations
- Locations (300)
Hospital Universitario Virgen Macarena /ID# 223315
🇪🇸Sevilla, Spain
Hospital Clinico Universitario de Valencia /ID# 223321
🇪🇸Valencia, Spain
Axler, Toronto, ON. Canada /ID# 223740
🇨🇦Toronto, Ontario, Canada
The University of Chicago DCAM /ID# 223520
🇺🇸Chicago, Illinois, United States
Duplicate_Baylor College of Medicine - Baylor Medical Center /ID# 223488
🇺🇸Houston, Texas, United States
University of Miami /ID# 223496
🇺🇸Miami, Florida, United States
AZ Maria Middelares /ID# 223908
🇧🇪Gent, Belgium
Acibadem City Clinic Tokuda University Hospital EAD /ID# 223757
🇧🇬Sofia, Bulgaria
Hospital Tsaritsa Yoanna /ID# 223822
🇧🇬Sofiya, Sofia, Bulgaria
2nd Mhat /ID# 223425
🇧🇬Sofia, Bulgaria
General Hospital of Chest Diseases of Athens SOTIRIA /ID# 223342
🇬🇷Athens, Attiki, Greece
Covenant Health /ID# 223753
🇨🇦Edmonton, Alberta, Canada
General Hospital of Athens Ippokratio /ID# 223344
🇬🇷Athens, Attiki, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 223338
🇬🇷Athens, Greece
General Hospital of Thessaloniki Hippokrateio /ID# 223887
🇬🇷Thessaloniki, Greece
The Edith Wolfson Medical Center /ID# 227652
🇮🇱Ashkelon, HaDarom, Israel
Sana Monitoring /Id# 223682
🇷🇴Bucharest, Romania
Oxford University Hospitals NHS Foundation Trust /ID# 223645
🇬🇧Oxford, Oxfordshire, United Kingdom
Gazi Universitesi Tip Fakultes /ID# 223386
🇹🇷Yenimahalle, Ankara, Turkey
Lviv Regional Clinical Hospital /ID# 223661
🇺🇦Lviv, Ukraine
Medical Center of LLC DIASERVIS /ID# 224249
🇺🇦Zaporizhzhia, Ukraine
IRCCS Ospedale Sacro Cuore Don Calabria /ID# 223327
🇮🇹Negrar, Verona, Italy
Duplicate_University of California, San Francisco /ID# 223621
🇺🇸San Francisco, California, United States
Clinical Associates in Research Therapeutics of America, LLC /ID# 223510
🇺🇸San Antonio, Texas, United States
Southern Star Research Institute, LLC /ID# 223598
🇺🇸San Antonio, Texas, United States
Mayo Clinic - Rochester /ID# 223506
🇺🇸Rochester, Minnesota, United States
TLC Clinical Research Inc /ID# 223467
🇺🇸Los Angeles, California, United States
Gastroenterology Group Naples /ID# 223516
🇺🇸Naples, Florida, United States
Duplicate_Western Connecticut Medical Group /ID# 223478
🇺🇸Danbury, Connecticut, United States
Gastroenterology Associates of Central Georgia, LLC /ID# 223525
🇺🇸Macon, Georgia, United States
Southern California Res. Ctr. /ID# 223484
🇺🇸Coronado, California, United States
United Medical Doctors /ID# 223486
🇺🇸Los Alamitos, California, United States
Massachusetts General Hospital /Id# 224335
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center /ID# 228094
🇺🇸Boston, Massachusetts, United States
Penn State Milton S. Hershey Medical Center /ID# 224216
🇺🇸Hershey, Pennsylvania, United States
Atlanta Gastro Assoc /ID# 223537
🇺🇸Atlanta, Georgia, United States
NY Scientific /ID# 223479
🇺🇸Brooklyn, New York, United States
AA Medical Research Center - Flint /ID# 224384
🇺🇸Flint, Michigan, United States
Texas Digestive Disease Consultants - Southlake /ID# 224264
🇺🇸Southlake, Texas, United States
Univ New Mexico /ID# 223515
🇺🇸Albuquerque, New Mexico, United States
Plains Clinical Research Center, LLC /ID# 223522
🇺🇸Fargo, North Dakota, United States
Duplicate_MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 223499
🇺🇸Chevy Chase, Maryland, United States
Intercity Advanced Gastroentertology Center /ID# 224313
🇺🇸Fresh Meadows, New York, United States
Digestive Disease Associates, LTD /ID# 223462
🇺🇸Wyomissing, Pennsylvania, United States
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinic /ID# 223465
🇺🇸Wyoming, Michigan, United States
University of Cincinnati Medical Center /ID# 224614
🇺🇸Cincinnati, Ohio, United States
Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 223512
🇺🇸Dallas, Texas, United States
Vilo Research Group Inc /ID# 223513
🇺🇸Houston, Texas, United States
Digestive Disease Specialists /ID# 223528
🇺🇸Oklahoma City, Oklahoma, United States
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto /ID# 223233
🇧🇷Ribeirão Preto, Sao Paulo, Brazil
Guthrie Medical Group, PC /ID# 223910
🇺🇸Sayre, Pennsylvania, United States
Mount Sinai Hospital /ID# 223752
🇨🇦Toronto, Ontario, Canada
Wollongong Hospital /ID# 224688
🇦🇺Wollongong, New South Wales, Australia
Scott Shulman Medicine Professional Corporation /ID# 223754
🇨🇦North Bay, Ontario, Canada
CHU de Liege /ID# 223904
🇧🇪Liege, Belgium
Duplicate_DHAT Research Institute /ID# 223521
🇺🇸Garland, Texas, United States
Virginia Mason Hospital & Medical Center /ID# 224253
🇺🇸Seattle, Washington, United States
Harborview Medical Center /ID# 224464
🇺🇸Seattle, Washington, United States
Tyler Research Institute, LLC /ID# 223469
🇺🇸Tyler, Texas, United States
Kaiser Clinica e Hospital Dia /ID# 223232
🇧🇷Sao Jose Do Rio Preto, Sao Paulo, Brazil
Faculdade de Medicina do ABC /ID# 223231
🇧🇷Santo André, La Spezia, Brazil
Duplicate_Sanatorio 9 de Julio /ID# 226086
🇦🇷San Miguel de Tucuman, Tucuman, Argentina
Duplicate_CHU UCL Namur - site Godinne /ID# 223905
🇧🇪Godinne, Namur, Belgium
Percuro Clinical Research, Ltd /ID# 223747
🇨🇦Victoria, British Columbia, Canada
Anhui Provincial Hospital /ID# 224832
🇨🇳Hefei, Anhui, China
Chongqing General Hospital /ID# 232305
🇨🇳Chongqing, Chongqing, China
Zhongshan Hospital Xiamen University /ID# 224663
🇨🇳Xiamen, Fujian, China
Hospital Guillermo Grant Benavente de Concepción /ID# 223668
🇨🇱Concepción, Chile
Montreal General Hospital- McGill University Health Center /ID# 223743
🇨🇦Montreal, Canada
CHUS - Hopital Fleurimont /ID# 224819
🇨🇦Sherbrooke, Quebec, Canada
Peking University Third Hospital /ID# 224479
🇨🇳Beijing, Beijing, China
Centre Medico Chirurgical Ambroise Pare Hartmann /ID# 249859
🇫🇷Neuilly Sur Seine, Ile-de-France, France
Zhujiang Hospital of Southern Medical University /ID# 224524
🇨🇳Guangzhou, Guangdong, China
Eugastro /ID# 223401
🇩🇪Leipzig, Sachsen, Germany
Medizinisches Versorgungszentrum Portal 10 /ID# 224552
🇩🇪Muenster, Germany
Medizinische Hochschule Hannover /ID# 223402
🇩🇪Hannover, Germany
Axon Clinical, s.r.o. /ID# 223260
🇨🇿Praha, Czechia
Universitatsklinikum Mannheim /ID# 223410
🇩🇪Mannheim, Baden-Wuerttemberg, Germany
CHU Reims - Hôpital Robert Debre /ID# 224530
🇫🇷Reims CEDEX, Marne, France
The Sixth Affiliated Hosp Sun /ID# 224416
🇨🇳Guangzhou, Guangdong, China
Ospedale San Raffaele IRCCS /ID# 241167
🇮🇹Milan, Milano, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 223332
🇮🇹Rome, Roma, Italy
CHU Montpellier - Hopital Saint Eloi /ID# 223860
🇫🇷Montpellier Cedex 5, Herault, France
Hopital Beaujon /ID# 223863
🇫🇷Clichy, Ile-de-France, France
Universitaetsklinikum Carl Gustav Carus an der TU Dresden /ID# 223403
🇩🇪Dresden, Germany
Renmin Hospital of Wuhan University /ID# 224525
🇨🇳Wuhan, Hubei, China
Universitaetsklinikum Frankfurt /ID# 223396
🇩🇪Frankfurt am Main, Hessen, Germany
Nemocnice Pardubickeho kraje, a.s. /ID# 223256
🇨🇿Pardubice, Czechia
The Second Xiangya Hospital of Central South University /ID# 224684
🇨🇳Changsha, China
Nanjing Drum Tower Hospital /ID# 224746
🇨🇳Nanjing, Jiangsu, China
Duplicate_CHU Grenoble - Hopital Michallon /ID# 224091
🇫🇷La Tronche, Isere, France
Praxiszentrum fuer Gastroenterologie /ID# 223409
🇩🇪Grevenbroich, Nordrhein-Westfalen, Germany
Klinikum Lueneburg /ID# 223408
🇩🇪Lueneburg, Germany
Duplicate_Agaplesion Markus Krankenhaus /ID# 223673
🇩🇪Frankfurt am Main, Hessen, Germany
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 223482
🇩🇪Saarbrücken, Saarland, Germany
Hopital Universitaire Purpan Hopital Rangueil /ID# 224732
🇫🇷Toulouse, France
Universitaetsklinikum Erlangen /ID# 223404
🇩🇪Erlangen, Bayern, Germany
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 224545
🇨🇳Wuhan, Hubei, China
CHRU Nancy - Hopitaux de Brabois /ID# 223767
🇫🇷Vandoeuvre-les-Nancy, Meurthe-et-Moselle, France
Renji Hospital, Shanghai Jiaotong University School of Medicine /ID# 224420
🇨🇳Shanghai, Shanghai, China
West China Hospital, Sichuan University /ID# 224786
🇨🇳Chengdu, Sichuan, China
CHU Clermont-Ferrand /ID# 224529
🇫🇷Clermont, Auvergne-Rhone-Alpes, France
APHM - Hopital Nord /ID# 223869
🇫🇷Marseille, Bouches-du-Rhone, France
Polyclinique Grand Sud /ID# 224092
🇫🇷Nimes Cedex, France
Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 223395
🇩🇪Kiel, Schleswig-Holstein, Germany
Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 223768
🇫🇷St-Priest-en-Jarez, France
Universitatsklinik Regensburg /ID# 223407
🇩🇪Ratisbon, Bayern, Germany
Universitaetsklinikum Freiburg /ID# 223406
🇩🇪Freiburg, Baden-Wuerttemberg, Germany
University General Hospital of Heraklion PA.G.N.I /ID# 223336
🇬🇷Heraklion, Kriti, Greece
Krankenhaus Waldfriede /ID# 223397
🇩🇪Berlin-Zehlendorf, Germany
Duplicate_Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 223405
🇩🇪Berlin, Germany
Ospedale Policlinico San Martino /ID# 223329
🇮🇹Genoa, Genova, Italy
Shaare Zedek Medical Center /ID# 223549
🇮🇱Jerusalem, Yerushalayim, Israel
ASST Rhodense/Presidio Ospedaliero di Rho /ID# 223335
🇮🇹Rho, Milano, Italy
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico /ID# 223324
🇮🇹Milan, Italy
Duplicate_Kangbuk Samsung Hospital /ID# 223452
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Medical Care & Research SA de CV /ID# 223974
🇲🇽Mérida, Yucatan, Mexico
Mersin University Medical /ID# 223385
🇹🇷Mersin, Turkey
Cabinet Particular Policlinic Algomed /ID# 223578
🇷🇴Timișoara, Romania
Barts Health NHS Trust /ID# 223651
🇬🇧London, London, City Of, United Kingdom
Guys and St Thomas NHS Foundation Trust /ID# 223647
🇬🇧London, London, City Of, United Kingdom
Universitätsspital Basel /ID# 223711
🇨🇭Basel Town, Basel-Stadt, Switzerland
Hospital Universitario Virgen del Rocio /ID# 223476
🇪🇸Sevilla, Spain
Danderyds sjukhus AB /ID# 223363
🇸🇪Stockholm, Sweden
Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 223387
🇹🇷Istanbul, Turkey
National Medical Research Center of Coloproctology n.a. A. N. Ryzhikh /ID# 224222
🇷🇺Moscow, Russian Federation
Hospital General Universitario de Alicante Doctor Balmis /ID# 223552
🇪🇸Alicante, Spain
Lenasia Clinical Trial Centre /ID# 224306
🇿🇦Johannesburg, Gauteng, South Africa
Ankara Univ Medical Faculty /ID# 223388
🇹🇷Ankara, Turkey
Calderdale and Huddersfield NHS Foundation Trust /ID# 223654
🇬🇧Huddersfield, United Kingdom
King's College Hospital NHS Foundation Trust /ID# 223649
🇬🇧London, United Kingdom
Belfast Health and Social Care Trust /ID# 224023
🇬🇧Belfast, United Kingdom
NHS Lothian /ID# 223646
🇬🇧Edinburgh, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 223655
🇬🇧Newcastle upon Tyne, United Kingdom
Northern Care Alliance NHS Group /ID# 223650
🇬🇧Salford, United Kingdom
NHS Forth Valley /ID# 224657
🇬🇧Stirling, United Kingdom
St George's University Hospitals NHS Foundation Trust /ID# 223656
🇬🇧Tooting, United Kingdom
Duplicate_University of South Florida /ID# 224733
🇺🇸Tampa, Florida, United States
Hightower Clinical /ID# 223566
🇺🇸Oklahoma City, Oklahoma, United States
Nemocnice Horovice - NH Hospital a.s /ID# 223276
🇨🇿Praha, Czechia
Griffith University /ID# 223641
🇦🇺Southport, Queensland, Australia
Saratoga Schenectady Gastroenterology Associates - Burnt Hills /ID# 224048
🇺🇸Burnt Hills, New York, United States
Columbia Univ Medical Center /ID# 224215
🇺🇸New York, New York, United States
Lenox Hill Hospital /ID# 223534
🇺🇸New York, New York, United States
Nature Coast Clinical Research - Inverness /ID# 223600
🇺🇸Inverness, Florida, United States
Advanced Research Institute, Inc /ID# 223470
🇺🇸New Port Richey, Florida, United States
Cleveland Clinic Main Campus /ID# 223691
🇺🇸Cleveland, Ohio, United States
Otto-von-Guericke-Universitaet /ID# 223413
🇩🇪Magdeburg, Germany
Omega Research Maitland, LLC /ID# 223463
🇺🇸DeBary, Florida, United States
Southwest Gastroenterology /ID# 223509
🇺🇸Oak Lawn, Illinois, United States
North Shore University Hospital /ID# 224356
🇺🇸New Hyde Park, New York, United States
The Mount Sinai Hospital /ID# 223687
🇺🇸New York, New York, United States
Gastroenterology Associates, P.A. of Greenville /ID# 223497
🇺🇸Greenville, South Carolina, United States
DSI Research, LLC /ID# 234116
🇺🇸Springboro, Ohio, United States
Gastro One /ID# 223539
🇺🇸Cordova, Tennessee, United States
Mater Misericordiae Limited /ID# 223642
🇦🇺South Brisbane, Queensland, Australia
Hospital Italiano de Buenos Aires /ID# 224550
🇦🇷Ciudad Autonoma Buenos Aires, Ciudad Autonoma De Buenos Aires, Argentina
Universitaetsklinikum St. Poelten /ID# 223437
🇦🇹Sankt Poelten, Niederoesterreich, Austria
Lyell McEwin Hospital /ID# 223643
🇦🇺Elizabeth Vale, South Australia, Australia
Universitair Ziekenhuis Leuven /ID# 223901
🇧🇪Leuven, Vlaams-Brabant, Belgium
Upeclin Fmb - Unesp /Id# 223234
🇧🇷Botucatu, Sao Paulo, Brazil
Allen Whey Khye Lim Professional Corporation /ID# 223755
🇨🇦Edmonton, Alberta, Canada
London Health Sciences Center- University Hospital /ID# 223741
🇨🇦London, Ontario, Canada
CISSS de la Monteregie /ID# 224399
🇨🇦Greenfield Park, Quebec, Canada
Sociedad de Servicios Medicos Walsen Galmez /ID# 224032
🇨🇱Santiago, Region Metropolitana De Santiago, Chile
Hospital Las Higueras /ID# 223669
🇨🇱Talcahuano, Chile
The Second Affiliated Hospital of Zhengzhou University /ID# 224528
🇨🇳Zhengzhou, Henan, China
Duplicate_The Third Xiangya Hospital of Central South University /ID# 224754
🇨🇳Changsha, Hunan, China
Tongji Hospital Tongji Medical College of HUST /ID# 224428
🇨🇳Wuhan, Hubei, China
Changzhou No.2 People's Hospital /ID# 238965
🇨🇳Changzhou, Jiangsu, China
Wuxi People's Hospital /ID# 224426
🇨🇳Wuxi, Jiangsu, China
The First Affiliated Hospital of Nanchang University /ID# 224507
🇨🇳Nanchang, Jiangxi, China
Shengjing Hospital of China Medical University /ID# 224478
🇨🇳Shenyang, Liaoning, China
The second affiliated hospital of Zhejiang University school of medicine /ID# 224662
🇨🇳Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine /ID# 224421
🇨🇳Hangzhou, Zhejiang, China
Iscare Klinické Centrum /ID# 223279
🇨🇿Prague, Praha 9, Czechia
Nemocnice Ceske Budejovice a.s. /ID# 224219
🇨🇿Ceske Budejovice, Czechia
Hepato-Gastroenterologie HK, s.r.o. /ID# 223277
🇨🇿Hradec Kralove, Czechia
CHRU Lille - Hopital Claude Huriez /ID# 223765
🇫🇷Lille, Nord, France
ASST Fatebenefratelli Sacco-Ospedale Sacco /ID# 223322
🇮🇹Milano, Italy
Clinique Jules Verne /ID# 223870
🇫🇷Nantes, France
Universitaetsklinikum Ulm /ID# 223400
🇩🇪Ulm, Baden-Wuerttemberg, Germany
Azienda Ospedaliera G. Brotzu /ID# 241165
🇮🇹Cagliari, Italy
Praxis Dr. Michael Mross /ID# 229110
🇩🇪Berlin, Germany
DRK Kliniken Berlin Westend /ID# 223412
🇩🇪Berlin, Germany
University General Hospital of Ioannina /ID# 223339
🇬🇷Ioannina, Greece
The Chaim Sheba Medical Center /ID# 223557
🇮🇱Ramat Gan, Tel-Aviv, Israel
Rabin Medical Center /ID# 223558
🇮🇱Haifa, Israel
Azienda Ospedaliera San Camillo Forlanini /ID# 223325
🇮🇹Rome, Roma, Italy
Azienda Ospedaliero Universitaria di Cagliari- Presidio Ospedaliero /ID# 223474
🇮🇹Cagliari, Italy
Policlinico Agostino Gemelli /ID# 223323
🇮🇹Rome, Roma, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 223330
🇮🇹Bologna, Italy
A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 223333
🇮🇹Palermo, Italy
Duplicate_Dong-A University Hospital /ID# 223455
🇰🇷서구, Gyeongsangnamdo, Korea, Republic of
Duplicate_The Catholic University of Korea, Daejeon St.Mary's Hospital /ID# 223456
🇰🇷중구, Daejeon Gwang Yeogsi, Korea, Republic of
Samsung Medical Center /ID# 223453
🇰🇷Seoul, Korea, Republic of
Amsterdam UMC, locatie AMC /ID# 223228
🇳🇱Amsterdam, Noord-Holland, Netherlands
Centro de Investigacion en Artritis y Osteoporosis S.C. /ID# 227179
🇲🇽Mexicali, Baja California, Mexico
BRCR Global Mexico /ID# 223970
🇲🇽Guadalajara, Jalisco, Mexico
Radboud Universitair Medisch Centrum /ID# 233750
🇳🇱Nijmegen, Gelderland, Netherlands
Centro Medico Zambrano Hellion /ID# 224025
🇲🇽San Pedro Garza Garcia, Nuevo Leon, Mexico
Elisabeth Tweesteden Ziekenhuis /ID# 223229
🇳🇱Tilburg, Netherlands
NZOZ Vivamed Jadwiga Miecz /ID# 223706
🇵🇱Warszawa, Mazowieckie, Poland
Universitair Medisch Centrum Utrecht /ID# 223696
🇳🇱Utrecht, Netherlands
Gastromed Sp. z o.o /ID# 223705
🇵🇱Torun, Kujawsko-pomorskie, Poland
Malopolskie Centrum Kliniczne /ID# 223708
🇵🇱Krakow, Malopolskie, Poland
Univ Emergency Hosp Bucharest /ID# 223579
🇷🇴Bucuresti, Romania
Duplicate_Institutul Clinic Fundeni /ID# 223914
🇷🇴Bucharest, Bucuresti, Romania
Spitalul Clinic Colentina /ID# 223680
🇷🇴Bucuresti, Romania
Spitalul Clinic Judetean de Urgenta Targu Mures /ID# 224017
🇷🇴Targu Mures, Romania
Targu Mures Emergency Clinical County Hospital /ID# 223613
🇷🇴Targu Mures, Romania
Duplicate_GASTRO I., s.r.o. /ID# 223303
🇸🇰Presov, Presovsky Kraj, Slovakia
City Clinical Hospital No. 31 /ID# 224223
🇷🇺St. Petersburg, Russian Federation
Spoke Research Inc /ID# 223803
🇿🇦CAPE TOWN Milnerton, Western Cape, South Africa
Hospital Arquitecto Marcide - Complejo Hospitalario Universitario de Ferrol /ID# 223356
🇪🇸Ferrol, A Coruna, Spain
Hospital Clínico Universitario de Santiago-CHUS /ID# 226554
🇪🇸Santiago de Compostela, A Coruna, Spain
Fakultna nemocnica s poliklinikou Nove Zamky /ID# 224580
🇸🇰Nove Zamky, Slovakia
Dr MJ Prins /ID# 224304
🇿🇦Cape Town, Western Cape, South Africa
Private Practice Dr MN Rajabally /ID# 223805
🇿🇦Cape Town, Western Cape, South Africa
Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 223302
🇸🇰Banska Bystrica, Slovakia
Hospital Universitario Puerta de Hierro - Majadahonda /ID# 223319
🇪🇸Majadahonda, Madrid, Spain
Duplicate_Hospital Universitario de Bellvitge /ID# 225719
🇪🇸L'Hospitalet de Llobregat, Barcelona, Spain
Hospital General Universitario Gregorio Maranon /ID# 223317
🇪🇸Madrid, Spain
Hospital Universitario Germans Trias i Pujol /ID# 223436
🇪🇸Badalona, Barcelona, Spain
Hospital Clinico Universitario San Carlos /ID# 223367
🇪🇸Madrid, Spain
Hospital Universitario La Paz /ID# 223318
🇪🇸Madrid, Spain
Hospital Universitario de Fuenlabrada /ID# 223371
🇪🇸Fuenlabrada, Madrid, Spain
Hospital Clinic de Barcelona /ID# 223355
🇪🇸Barcelona, Spain
Hospital Universitario y Politecnico La Fe /ID# 223314
🇪🇸Valencia, Spain
GHP Stockholm Gastro Center /ID# 223420
🇸🇪Stockholm, Stockholms Lan, Sweden
Duplicate_Falu Lasarett /ID# 227222
🇸🇪Falun, Sweden
Karolinska University Hospital Solna /ID# 223423
🇸🇪Solna, Stockholms Lan, Sweden
Royal Devon & Exeter Hospital /ID# 223644
🇬🇧Exeter, Devon, United Kingdom
East and North Hertfordshire NHS Trust /ID# 224607
🇬🇧Stevenage, Hertfordshire, United Kingdom
Gastro Center of Maryland /ID# 223518
🇺🇸Columbia, Maryland, United States
Hoag Memorial Hosp Presbyterian /ID# 224373
🇺🇸Irvine, California, United States
NorthShore University HealthSystem /ID# 223538
🇺🇸Evanston, Illinois, United States
QEII - Health Sciences Centre /ID# 223748
🇨🇦Halifax, Nova Scotia, Canada
Nola Research Works, LLC /ID# 223489
🇺🇸New Orleans, Louisiana, United States
Univ NC Chapel Hill /ID# 224405
🇺🇸Chapel Hill, North Carolina, United States
Richmond VA Medical Center /ID# 223586
🇺🇸Richmond, Virginia, United States
Duplicate_UC Davis Medical Center /ID# 225700
🇺🇸Sacramento, California, United States
Yale Univ Digestive Diseases /ID# 224463
🇺🇸New Haven, Connecticut, United States
Endoscopic Research, Inc. /ID# 223505
🇺🇸Orlando, Florida, United States
University of Louisville Hospital /ID# 223471
🇺🇸Louisville, Kentucky, United States
University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 223597
🇺🇸Ann Arbor, Michigan, United States
Atrium Health Wake Forest Baptist Medical Center /ID# 224406
🇺🇸Winston-Salem, North Carolina, United States
Advanced Gastroenterology, P.C /ID# 224396
🇺🇸Chandler, Arizona, United States
Las Vegas Medical Research /ID# 223533
🇺🇸Las Vegas, Nevada, United States
Duplicate_Medical Research Center of CT /ID# 223540
🇺🇸Hamden, Connecticut, United States
Consultants in Gastroenterology - Columbia NE /ID# 224263
🇺🇸Columbia, South Carolina, United States
Vanderbilt University Medical Center /ID# 224610
🇺🇸Nashville, Tennessee, United States
Medical University of South Carolina /ID# 223485
🇺🇸Charleston, South Carolina, United States
GI Alliance /ID# 223508
🇺🇸Baton Rouge, Louisiana, United States
Louisiana Research Center, LLC /ID# 223503
🇺🇸Shreveport, Louisiana, United States
University of Vermont Medical Center /ID# 224047
🇺🇸Burlington, Vermont, United States
CINME Centro de Investigaciones Metabolicas /ID# 223447
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Gedyt /ID# 224698
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Hospital Britanico de Buenos Aires /ID# 223432
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Cemic /Id# 223670
🇦🇷Ciudad Autonoma de Buenos Aire, Ciudad Autonoma De Buenos Aires, Argentina
Hospital Privado Universitario - Hospital Privado Centro Medico de Cordoba S.A. /ID# 223433
🇦🇷Cordoba, Argentina
Ordensklinikum Linz GmbH Barmherzige Schwestern /ID# 223440
🇦🇹Linz, Oberoesterreich, Austria
Medizinische Universitaet Wien /ID# 223438
🇦🇹Vienna, Wien, Austria
Universite Libre de Bruxelles - Hopital Erasme /ID# 223902
🇧🇪Anderlecht, Bruxelles-Capitale, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 223900
🇧🇪Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
UZ Gent /ID# 223899
🇧🇪Gent, Oost-Vlaanderen, Belgium
Vitaz /Id# 224511
🇧🇪Sint-Niklaas, Oost-Vlaanderen, Belgium
AZ-Delta /ID# 223896
🇧🇪Roeselare, West-Vlaanderen, Belgium
Groupe Sante CHC - Clinique du MontLegia /ID# 223898
🇧🇪Liege, Belgium
ZNA - Jan Palfijn /ID# 223907
🇧🇪Merksem, Belgium
University of Calgary /ID# 223750
🇨🇦Calgary, Alberta, Canada
UMHAT Kaspela EOOD /ID# 223415
🇧🇬Plovdiv, Bulgaria
CSSS Alphonse-Desjardins, CHAU de Levis /ID# 223744
🇨🇦Levis, Quebec, Canada
West Virginia University Hospitals /ID# 223501
🇺🇸Morgantown, West Virginia, United States
Monash Medical Centre /ID# 224599
🇦🇺Clayton, Victoria, Australia
CHU de Nantes, Hotel Dieu -HME /ID# 241098
🇫🇷Nantes, Pays-de-la-Loire, France
Chu de Nice-Hopital Larchet Ii /Id# 223763
🇫🇷Nice, Alpes-Maritimes, France
Duplicate_CHU Bordeaux - Hopital Haut Leveque /ID# 223764
🇫🇷Pessac, Gironde, France
General Hospital of Nikaia-Piraeus "Agios Panteleimon" /ID# 223340
🇬🇷Nikaia, Greece
Yitzhak Shamir Medical Center /ID# 224686
🇮🇱Zerifin, HaMerkaz, Israel
Immanuel Kant Baltic Federal University /ID# 224224
🇷🇺Kaliningrad, Kaliningradskaya Oblast, Russian Federation
KM Management, spol. s.r.o. /ID# 223304
🇸🇰Nitra, Nitriansky Kraj, Slovakia
Kyiv City Clinical Hospital No.18 /ID# 223700
🇺🇦Kyiv, Ukraine
University Hospital Southampton NHS Foundation Trust /ID# 224351
🇬🇧Southampton, Hampshire, United Kingdom
Duplicate_Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont /ID# 223774
🇭🇺Szeged, Csongrad, Hungary
Duplicate_Clinfan Szolgaltato Kft. /ID# 224751
🇭🇺Szekszard, Tolna, Hungary
Tel Aviv Sourasky Medical Center /ID# 223551
🇮🇱Tel Aviv, Tel-Aviv, Israel
Duplicate_Debreceni Egyetem Klinikai Kozpont /ID# 223773
🇭🇺Debrecen, Hajdu-Bihar, Hungary
Soroka University Medical Center /ID# 223556
🇮🇱Be'er Sheva, HaDarom, Israel
Faicic S de Rl de Cv /Id# 226990
🇲🇽Veracruz, Mexico
Inselspital, Universitaetsspital Bern /ID# 223590
🇨🇭Bern, Switzerland
Duplicate_Nottingham University Hospitals NHS Trust /ID# 224179
🇬🇧Nottingham, Nottinghamshire, United Kingdom
Hospital Universitario Central de Asturias /ID# 223368
🇪🇸Oviedo, Asturias, Spain
NHS Greater Glasgow and Clyde /ID# 223653
🇬🇧Glasgow, Scotland, United Kingdom
Semmelweis Egyetem /ID# 223772
🇭🇺Budapest, Hungary
Duplicate_Universitatsspital Zurich /ID# 223712
🇨🇭Zurich, Zuerich, Switzerland
Addenbrooke's Hospital /ID# 223648
🇬🇧Cambridge, Cambridgeshire, United Kingdom
MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 223411
🇩🇪Berlin, Germany
Fraser Clinical Trials Inc /ID# 223742
🇨🇦New Westminster, British Columbia, Canada
Clinexpert Kft /ID# 223775
🇭🇺Budapest, Hungary