Cinnarizine and sodium valproate in prophylaxis of pediatric migraine .
Not Applicable
- Conditions
- Migraine.Migraine
- Registration Number
- IRCT201206306907N4
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
Patients with migraine (with or without aura), diagnosed according to the International Headache society criteria
Patients who had at least four migraine attacks per 4 weeks; or sever dysfunction in daily and school activities during prospective baseline phase.
Exclusion Criteria
Chronic headache, complications of migraine or other migraine variant
Children and adolescents with Focal neurologic deficit
History of diagnosed sensitivity to each of drugs that used in the study
Patients who took prophylactic therapy for migraine within 8 weeks before study.
Headaches related to structural brain lesions
Pregnancy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Frequency of headache. Timepoint: frequency of frequency of each attack in a month. Method of measurement: questionnaire.;Intensity of headache. Timepoint: intensity of each attack. Method of measurement: Visual analogue scale (VAS).
- Secondary Outcome Measures
Name Time Method Adverse effects. Timepoint: in the double-blind phase of the study. Method of measurement: ask from participants and parents.;More than 50% responder rate. Timepoint: in the double-blind phase of the study and baseline. Method of measurement: ask from participants and parents.