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临床试验/NCT07171788
NCT07171788尚未招募不适用

Effects of Low Level Laser Therapy on Wrist Flexors Spasticity and Hand Functions in Patients With Stroke

Cairo University0 个研究点目标入组 40 人开始时间: 2025年9月15日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
40
主要终点
spasticity

研究概览

简要总结

this study will be conducted to investigate the effect of low level laser therapy (LLLT) on wrist flexors spasticity and hand functions in patient with stroke

详细描述

Spasticity is more often found in the flexors muscles of the upper limb (fingers, wrist, and elbow flexors) and extensor muscles of the lower limb (knee and ankle extensors). Wissel et al observed that spasticity developed most often in elbow (79%), wrist (66%), ankle (66%), and shoulder (58%).9 Lundstrom et al concluded that spasticity is observed more frequently in the upper extremities than in the lower extremities, and Urban et al found a higher degree of spasticity in the upper limb muscles. LLLT is thought to work through several mechanisms. Stimulating ATP production and increasing cellular energy. The therapy can cause vasodilation, improving circulation in the treated area. It may also reduce the production of inflammatory mediators and increase anti-inflammatory factors, while potentially stimulating the synthesis of growth-promoting factors that facilitate tissue healing, and renewal may be stimulated by this therapy. In the context of spasticity management, LLLT has garnered scientific interest as a possible intervention, although its efficacy remains under scrutiny .Hypothesized mechanisms of action include muscle tone reduction through enhanced circulation and decreased inflammation in muscular and adjacent tissues, potentially fostering the relaxation of hypertonic muscles. Certain research indicates that LLLT may modulate the release of neurotransmitters crucial to muscle contraction and relaxation processes.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Outcomes Assessor)

盲法说明

opaque sealed envelope

入排标准

年龄范围
45 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • forty stroke patients with wrist flexors spasticity from both sex will be participate in this study
  • Their age ranges from 45 to 60 years.
  • Patients will be referred by neurological consultants.
  • preserved cognitive system, i.e., ability to respond to verbal stimul
  • Body mass index less than
  • Patients will be diagnosed by clinical and radiological examination.
  • patients with wrist flexors spasticity according to modified ashworth scale score +1 to 2.

排除标准

  • Patients with contractures, fractures, rigidity, and deformity
  • Patients with cognitive impairments.
  • Patients with visual, auditory impairment affecting their ability to complete tasks.
  • Uncontrolled Diabetic patient.
  • Presence of hypoesthesia and/or hyperesthesia of the involved upper limb.
  • Other major neurological condition (e.g., Spinal cord injury, multiple sclerosis, Epilepsy, Meningitis, and Brain tumor).
  • presence of neoplastic lesions at the site of application

结局指标

主要结局

spasticity

时间窗: up to 6 weeks

Modified ashworth scale will be used to assess spaticity according the following criteria,0: No increase in muscle tone 1. Slight increase in muscle tone, with a catch and release or minimal resistance at the end of the range of motion when an affected part(s) is moved in flexion or extension 1+: Slight increase in muscle tone, manifested as a catch, followed by minimal resistance through the remainder (less than half) of the range of motion 2. A marked increase in muscle tone throughout most of the range of motion, but affected part(s) are still easily moved 3. Considerable increase in muscle tone, passive movement difficult 4. Affected part(s) rigid in flexion or extension

hand grip strength

时间窗: up to 6 weeks

hand held dynamometer will be used to assess hand grip strength

muscle stiffness

时间窗: up to 6 weeks

The MyotonPRO will be used to assess muscle stiffness. it is a new handheld device that conveniently assesses stiffness of muscles and tendons.the device effectively measures changes in muscle stiffness due to fatigue It is placed on the skin over the muscle. A brief, gentle tap from the probe causes the muscle to oscillate. The oscillations are analysed automatically by the device to calculate the muscle's mechanical characteristics, such as its tone, stiffness and how elastic it is.

次要结局

  • pain intensity(up to 6 weeks)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Heba Hassan Amin Mohamed

principle investigator : heba hassan amin mohamed

Cairo University

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